UDP-glucuronosyltransferase A1 (UGT2A1) is expressed in the lung and exhibits activity against polycyclic aromatic hydrocarbons (PAHs), suggesting UGT2A1 involvement in the local metabolism of PAH tobacco carcinogens. The goal of the present study was to investigate the importance of two additional UGT2A enzymes, UGT2A2 and UGT2A3, in tobacco carcinogen metabolism. Realtime polymerase chain rea...

Deferasirox is an orally effective iron (Fe) chelator currently used for the treatment of iron-overload disease and has been implemented as an alternative to the gold standard chelator, desferrioxamine (DFO). Earlier studies demonstrated that DFO exhibits anticancer activity due to its ability to deplete cancer cells of iron. In this investigation, we examined the in vitro and in vivo activity ...

Studies on signalling dynamics in living embryos have been limited by a scarcity of in vivo reporters. Tandem fluorescent protein timers provide a generic method for detecting changes in protein population age and thus provide readouts for signalling events that lead to changes in protein stability or location. When imaged with quantitative dual-colour fluorescence microscopy, tandem timers off...

Southern African countries have a good cultural tourism development potential, and many countries in the region have identifi ed the development of cultural tourism as one of the key growth areas in tourism. A specifi c element of cultural tourism is based on crafts that are sold for visitors in various sites and market places. Crafts and craft markets are relatively visible in the Southern Afr...

This study was conducted to evaluate retrospectively 203 patients diagnosed with hydatid cyst disease and treated surgically at two university medical centers between 1999 and 2009 in Tehran, the capital of Iran. Cystic echinococcosis (CE) affected more females 117 (57.6%) than males 86 (42.4%). A remarkable gender difference skewed towards females was observed, and the male/female ratio among ...

Inclusive business is described as private sector-led business initiatives that aim to profi tably engage low-income populations across productive value chains. Th is paper aims to quantify the impact of businesses implementing inclusive business strategies to determine the value to local communities as well as the tourism business. Th e research reviews the direct impact of the business on com...

Complete or partial agenesis of the corpus callosum are rather common developmental abnormalities, resulting in a wide spectrum of clinical neurodevelopmental deficits. Currently, a significant number of these cases are detected by prenatal sonography during second trimester screening examinations. However, major uncertainties about a detailed morphological diagnosis and the clinical significan...

Epidemiological studies have firmly demonstrated that human papillomaviruses (HPVs), are established causes of anogenital cancers (Schiffman,1995, Das et al, 2000, Kirwan & Herrington, 2001). HPV 16 and 18 are the most prevalent types in cervical lesions (Van den Brule et al, 1993). Low risk HPV types 6 and 11, in contrast, are mainly associated with recurrent laryngeal papillomatosis and genit...

Change in tumor size estimated using longitudinal tumor growth inhibition (TGI) modeling is an early predictive biomarker of clinical outcomes for multiple cancer types. We present the application of TGI modeling for subjects with multiple myeloma (MM). Longitudinal time course changes in M-protein data from relapsed and/or refractory MM subjects who received single-agent carfilzomib in phase I...