Japan is one of the countries where the percentage of smokers is still notoriously high. The percentage of people smoking among those aged 20 years or over in 1995 was reported by the National Survey on Nutrition to be 52.7% in males and 10.6% in females (Health and Welfare Statistics Association, 1997). It has been estimated that considerable numbers of cigarettes are now being consumed by ado...

Behavioral effects of OM-853 were investigated in both mice and Mongolian gerbils. In mice, OM-853 alone produced no marked change in the ambulatory activity, although it tended to lower it at 100 mg/kg, and this drug (5-100 mg/kg, p.o.) reduced the ambulation-increasing effect of scopolamine (0.5 mg/kg, s.c.) in a dose-dependent manner. Moreover, OM-853 (50 and 100 mg/kg, p.o.) prolonged the l...

The transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is expressed in a broad range of tissues. Nitric oxide (NO) as a gaseous signal mediator shows a variety of important biological effects. In many instances, NO has been shown to exhibit its activities via a protein S-nitrosylation mechanism in order to regulate its protein functions. Wi...

JTK-853, a palm site-binding NS5B nonnucleoside polymerase inhibitor, shows antiviral activity in vitro and in hepatitis C virus (HCV)-infected patients. Here, we report the results of genotypic and phenotypic analyses of resistant variants in 24 HCV genotype 1-infected patients who received JTK-853 (800, 1,200, or 1,600 mg twice daily or 1,200 mg three times daily) in a 3-day monotherapy. Vira...

http://jom.sagepub.com/content/39/4/853 The online version of this article can be found at: DOI: 10.1177/0149206311419662 2013 39: 853 originally published online 1 September 2011 Journal of Management Jinseok S. Chun, Yuhyung Shin, Jin Nam Choi and Min Soo Kim Citizenship Behavior Mediating Role of Collective Organizational Commitment and Organizational How Does Corporate Ethics Contribute to ...

Epithelial cells lining the inner surface of the intestinal epithelium are in direct contact with a lumenal environment that varies dramatically with diet. It has long been suggested that the intestinal epithelium can sense the nutrient composition of lumenal contents. It is only recently that the nature of intestinal nutrient-sensing molecules and underlying mechanisms have been elucidated. Th...

In this Paper, we propose an automatic speech disorders recognition technique based on both speech and visual components analysis. First, we performed the pre-processing steps required for speech recognition then we chose the Mel-frequency cepstral coefficients (MFCC's) as features representing the speech signal.On the other hand, we studied the visual components based on lipsmovements analysis...

Epidermolysis bullosa (EB) refers to a group of monogenic disorders characterized by skin fragility with marked variations in phenotypic expression suggesting co-inheritance genetic modifiers. We identified four pathogenic variants the HMCN1 gene that co-segregated more severe phenotype 4 families EB simplex caused KRT14 mutations, and one family dystrophic EB. encodes hemicentin 1 (HMCN1) whic...