Stress affects already young healthy people and many elderly or patients with psychiatric disorders receive benzodiazepines. A recent study has shown that the phyto-anxiolytic herbal extract combination Ze 185 (Relaxane®) significantly reduced the subjective stress reaction in healthy men in an acute stress setting. Further, in a retrospective data analysis from stationary patients in a psychia...

congenital factor xiii deficiency is a very rare bleeding disorder, but because of the high rate of consanguineous marriages, it is common in sistan and baluchestan province of iran. the discovery of promoter hypermethylation of numerous mirnas in human diseases has demonstrated an epigenetic mechanism for aberrant mirna expression. the present study has analyzed methylation and expression stat...

The aim of the present study was to compare the expression of transcriptional coactivator with the PDZ-binding motif (TAZ) in pancreatic cancer (PC) patients, and to investigate the regulation mechanisms of TAZ in the proliferation of PC. PC tissues and matched peritumoral tissues, pancreatic juice and serum were collected from PC patients who underwent pancreatectomy between June 2012 and Dece...

Although many components of the genetic pathways that provide positional information during embryogenesis have been identified, it remains unclear how these signals are integrated to specify discrete tissue territories. Here, we investigate the molecular mechanisms underlying the formation of one of the hindbrain segments, rhombomere (r) 3, specified by the expression of the gene krox20. Dissec...

Mononuclear leukocytes are able to destroy tumor cells under a variety of circumstances. In few such instances is the biochemical basis of cytotoxicity understood. Recently, we demonstra ted that activated macrophages, s t imulated by phorbol myristate acetate (PMA), 1 secreted substantial amounts o f hydrogen peroxide (1). The release o f this oxidant from macrophages correlated with the extra...

Human embryonic stem cells (hESCs) are routinely cultured on fibroblast feeder layers or in fibroblast-conditioned medium (CM). Bone morphogenetic proteins (BMPs) have previously been shown to induce hESC differentiation, in apparent contrast to mouse embryonic stem (ES) cells, in which BMP4 synergizes with leukemia inhibitory factor (LIF) to maintain self-renewal. Here we demonstrate that hESC...

Pneumocystis pneumonia (PCP) is one of the common opportunistic infection among HIV and non-HIV immunocompromised patients. The lack of a rapid and specific diagnostic test necessitates a more reliable laboratory diagnostic test for PCP. In the present study, the loop-mediated isothermal amplification (LAMP) assay was evaluated for the detection of Pneumocystis jirovecii. 185 clinical respirato...

We have recently characterized two lymphocyte-associated membrane proteins which have been termed 225,000-dalton and 185,000-dalton macromolecular insoluble cold globulin (225-MICG and 185-MICG, respectively) to distinguish their major physicochemical properties. These proteins differ antigenically, structurally, and in their cellular distribution. T cells can be distinguished by the synthesis ...

Subduction zones are the primary regions on Earth today where crust recycling takes place, and through geological time they have been the sites of continent formation. Many of the key elements (e.g., Th, rare earth elements, Ba, and Be) that are important in understanding crustal growth are sequestered in the sedimentary column and in the uppermost oxidized portions of the volcanic section of o...