Abstract Red fruit oil (RFO) can be extracted from fruits of Pandanus conoideus, Lam., an endogenous plant Papua, Indonesia. It is a commonly used essential original traditional medicine. By applying newly developed quantitative 1 H NMR (qNMR) spectroscopy method for quality assessment, simultaneous determination the saponification value (SV), acid (AV), ester (EV), and iodine (IV) in RFO was p...

The analysis of Celandine extracts (Chelidonium majus L.) by 1H NMR method makes it possible to identify the main alkaloids – derivatives phenanthridine, protoberberin and protopin, use qNMR provides information with satisfactory accuracy about content these alkaloids. determined in composition (0.35%) is 2 times lower than when using spectrophotometric determination procedure described GF Russ...

The constitution of vacidin A, a representative of the aromatic heptaene macrolide antibiotics was established on the basis of 13C and 1H-1H double quantum filtered correlated spectroscopy, rotating frame nuclear Overhauser effect spectroscopy, J-resolved 1H as well as 1H-13C correlation NMR spectra. Geometry of the polyene chromophore was determined as 22E,24E,26E,28Z,30Z,32E,34E.

Given the critical role of pure, organic compound primary reference standards used to characterize and certify chemical Certified Reference Materials (CRMs), it is essential that associated mass purity assessments be fit-for-purpose, represented by an appropriate uncertainty interval, and metrologically sound. The mass fraction purities (% g/g) of 25-hydroxyvitamin D (25(OH)D) reference standar...

The structure of a novel antibiotic, epiderstatin, was determined as 4-[3-((Z)-3,5-dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl]-2, 6-piperidinedione by spectroscopic analyses of 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, UV and IR spectra. The antibiotic belongs to the glutarimide antibiotics, however, the charac...

As a new absolute quantitation method for low-molecular compounds, quantitative NMR (qNMR) has emerged. In the Japanese Pharmacopoeia (JP), 15 compounds evaluated by qNMR are listed as reagents used HPLC reference standards in assay of crude drug section JP. previous study, we revealed that humidity affects purity values hygroscopic and (i) control before during weighing is important reproducib...

Toxicologically relevant levels of the psychoactive ?9-tetrahydocannabinol (?9-THC) as well high non-psychoactive cannabinoids potentially occur in CBD (cannabidiol) oils. For consumer protection fast-growing oil market, facile and rapid quantitative methods to determine cannabinoid content are crucial. However, current standard method, i.e., liquid chromatography combined with tandem mass spec...

In any biomedical and chemical context, a truthful description of chemical constitution requires coverage of both structure and purity. This qualification affects all drug molecules, regardless of development stage (early discovery to approved drug) and source (natural product or synthetic). Purity assessment is particularly critical in discovery programs and whenever chemistry is linked with b...