The reactions of ruthenium trichloride with Schiff bases derived from sulpha drugs in 1:2 molar ratio leads to the formation of a new series of coordination compounds of type [Ru(L) 2 (H 2 O)Cl]. The Schiff bases used here are o-Vanillin sulphanilamide (oVSaH), o-Vanillin sulphamerazine (oVSmrzH), salicylaldehyde sulphanilamide (SdSaH), salicylaldehyde sulphamerazine (SdSmrzH), 2-hydroxy-1-naph...

Herein, we report a Pd4L2-type molecular cage (1) and catalyzed reactions of spiroepoxy naphthalenone (2) in water, where selective formation 2-(hydroxymethyl)naphthalene-1,4-dione (3) via aerobic oxidation, or 1-hydroxy-2-naphthaldehyde (4) photo-induced rearrangement under N2 have been accomplished. Encapsulation four molecules guest 2 within 1, i.e., (2)4⊂1, has confirmed by NMR, final host-...

An efficient fluorescent Al(3+) receptor, N-(2-hydroxy-1-naphthalene)-N'-(2-(2-hydroxy-1-naphthalene)amino-ethyl)-ethane-1,2-diamine (L) has been synthesized by the condensation reaction between 2-hydroxy naphthaldehyde and diethylenetriamine. High selectivity and affinity of L towards Al(3+) in ethanol (EtOH) as well as in HEPES buffer at pH 7.4, makes it suitable to detect intracellular Al(3+...

Potential energy (PE) curves for the intramolecular proton transfer in the ground (GSIPT) and excited (ESIPT) states of 1-hydroxy-2naphthaldehyde (1H2NA) and 2-hydroxy-3-naphthaldehyde (2H3NA) were studied using DFT/B3LYP(6-31G) and TD-DFT/ B3LYP(6-31G) level of theory, respectively. Our calculations suggest the non-viability of ground state intramolecular proton transfer for both the compounds...

Potentiometric studies have been carried out on transition metal complexes of Mn+2, Co+2, Ni+2, Cu+2, Zn+2 with hydrazones synthesized from 4-amino benzoic acid hydrazide and 2-hydroxy-1acetonephthone/2-hydroxy-1-naphthaldehyde. The dissociation constants of ligand and formation constants of its metal complexes have been determined by Calvin-Bjerrum pH titration technique, as adopted by Irving ...

Endoplasmic reticulum stress from unfolded proteins is associated with the proliferation of pancreatic tumor cells, making the many regulatory molecules of this pathway appealing targets for therapy. The objective of our study was to assess potential therapeutic efficacy of inhibitors of unfolded protein response (UPR) in pancreatic cancers focusing on IRE1α inhibitors. IRE1α-mediated XBP-1 mRN...

A facile and inexpensive synthesis of a series of novel methylenedioxy-bearing 2-(benzofuran-2-yl)-quinoline-3-carboxylic acid derivatives 3a-h via the one-pot reaction of ethyl 2-chloromethyl-6,7-methylenedioxyquinoline-3-carboxylate (5) with various substituted salicylaldehydes 6a-g as well as 2-hydroxy-1-naphthaldehyde (6h) is described. Substrate 5 was synthesized by the Friedländer condens...

Investigations on a series of eight novel mononuclear iron(III) Schiff base complexes with the general formula [Fe(L(5))(L(1))]·S (where H(2)L(5) = pentadentate Schiff-base ligand, L(1) = a pseudohalido ligand, and S is a solvent molecule) are reported. Several different aromatic 2-hydroxyaldehyde derivatives were used in combination with a non-symmetrical triamine 1,6-diamino-4-azahexane to sy...

A new photochromic system based on 2-(4-hydroxystyryl)-1-naphthopyrylium encompasses the properties of the previously described naphthoflavylium and styrylflavylium systems. The photoproduct exhibits a colour deep in hue and is red shifted in comparison with the equivalent flavylium system. Reaction of 2-hydroxy-1-naphthaldehyde with p-hydroxystyrylmethylketone in acetic acid in the presence of...