GL-2045 is a recombinant human immunoglobulin G1 (IgG1)-based Fc multimer designed to recapitulate the anti-inflammatory activities of intravenous immunoglobulin (IVIG) on the innate and adaptive immune responses. We used functional in vitro studies to determine if GL-2045 could mimic the modulatory activity of IVIG on complement activation. GL-2045, at log-order lower concentrations than heat-...

There is an error in the antepenultimate sentence of the abstract. The number of treatments is incorrect. The correct sentence is: The control scenario requires community-directed treatment with ivermectin beyond 2045 with around 2.63 billion treatments over 2013–2045; the elimination scenario, until 2028 in areas where feasible, but beyond 2045 in countries with operational challenges, around ...

Droplet-based microfluidics provides an excellent platform for high-throughput biological assays. Each droplet serves as a reaction vessel with a volume as small as a few picolitres. This is an important technology for a high variety of applications. However this technology is restricted to homogeneous assays as it is very difficult to wash reagents from the reaction vessel. To help overcome th...

Global warming due to greenhouse effect is expected to cause major changes in climate of some regions. The change of climate is likely to have a profound effect on hydrological cycle. Evapotranspiration (ET, as the major component of hydrological cycle, will affect crop water requirement and future planning and management of water resources. This study was conducted to investigate climate chang...

Previous studies have found alterations in the columnar organization of the cortex in autism spectrum disorders. Such changes have been suggested to be limited to higher order association areas and to spare primary sensory areas. In addition, evidence from geneexpression studies have suggested that there may be an attenuation of cortical differentiation in autism spectrum disorders. The present...

Despite the importance of tendons and ligaments for transmitting movement and providing stability to the musculoskeletal system, their development isconsiderably lesswell understood than thatof the tissues they serve to connect. Zebrafish have been widely used to address questions inmuscle and skeletal development, yet few studies describe their tendon and ligament tissues. We have analyzed in ...

Temperature and precipitation from 16 climate models each using two emissions scenarios (lower B1 and mid-high A2) were used to characterize the range of potential climate changes for the Rio Lempa basin of Central America during the middle (2040–2069) and end (2070–2099) of the 21st century. A land surface model was applied to investigate the hydrologic impacts of these changes, focusing on in...

The diminishing spring discharge in the Middle Mountain Zone (MMZ) Nepal is a matter of concern because it directly affects livelihoods low-income farmers region. Therefore, understanding impacts changes climate and land-use patterns on water demand availability crucial. We investigated impact change streamflow environmental flow, for spring-fed river irrigation using limited meteorological dat...

One of the major factors, contributing to the emission of greenhouse gases in the environment is generation of pollutant gases in municipal landfills. As for the design and building of a gas collecting system, it is necessary to properly estimate the amount and type of the landfill emissions. By means of LandGEM model, this study predicts the amount and type of the landfill gases, produced for ...