Twenty-five Landrace • Yorkshire sows (second through seventh parity) were randomly assigned to five dietary treatments in an experiment designed to estimate the isoleucine requirement of the sow during the first 3 weeks of lactation. The basal diet (.20% isoleucine), composed of oat groats, corn sugar, wood cellulose, soybean oil, vitamins, minerals, indispensable amino acids and L-glutamic ac...

(1) The levels of oleate and linoleate in the serum have been measured in 14 patients with multiple sclerosis (MS) and in 14 healthy subjects before, during and after a five day period when the normal diet was supplemented with linoleate. (2) In confirmation of earlier work the mean percentage of linoleate in the serum lipids of the MS patients was significantly lower (P < 0·01) than in the con...

The effects of orally administered diltiazem combined with maximally tolerated doses of beta-blockers and nitrates were assessed in 12 patients, who during stress testing exhibited persistent effort angina and continued objective evidence for inducible myocardial ischemia. Patients performed multistage semisupine exercise on a bicycle ergometer during equilibrium-gated radionuclide angiography ...

Injury potential may have a regulatory role in the wound healing process, and exogenous electrical stimulation (ES) may mimic natural endogenous bioelectric current that can improve wound healing. Until now, the influence of externally applied ES on injury potential has not been demonstrated during the healing of acute wounds. Thirty-nine male guinea pigs were randomly divided into a control gr...

PURPOSE Temozolomide (TMZ) is an alkylating agent licensed for treatment of high-grade glioma (HGG). No prospective comparison with nitrosourea-based chemotherapy exists. We report, to our knowledge, the first randomized trial of procarbazine, lomustine, and vincristine (PCV) versus TMZ in chemotherapy-naive patients with recurrent HGG. PATIENTS AND METHODS Four hundred forty-seven patients w...

This report examines the effects on hematopoietic regeneration of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) (2.5 micrograms/ kg/d) alone and in combination with recombinant human granulocyte colony stimulating factor (rHu-GCSF) (10 micrograms/ kg/d) for 21 days in rhesus macaques receiving intense marrow suppression produced by single bolus injections...

Total Time. By day five, the average total time was 805 ms for 1HR and 682 ms for 2HS, reduced from 932 ms and 823 ms respectively on day one. Menu technique (p = .005) and day (p = .009) had significant effects on total time, but there was no interaction effect (F4,16 = 0.308, p = .869). Reaction Time. By day five, the average reaction time was 590 ms for 1HR and 533 ms for 2HS, reduced from 5...

A prospective trial to demonstrate the efficacy of intrathecal baclofen therapy by implanted pump for adults with spasticity due to spinal cord injury or multiple sclerosis was initiated in our hospital. Of the 140 patients assessed, 7 met the following criteria for inclusion in the study: a modified Ashworth score > 3, a spasm frequency score > 2, and an inadequate response to oral anti-spasti...

The nephrotoxicity of tobramycin given at a dose of 4.5 mg/kg/day for a period of 12 days to a group of 90 patients with a mean age of 62.9 years was studied. Toxicity was determined on the basis of 3 main criteria (oliguria <400 ml/24 hr, serum creatinine 0.4 mg increase over a minimum basal level of 1.2 mg/100 ml, BUN 5 mg increase over a minimum of 25 mg/100 ml); and 3 minor criteria (protei...

A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (Ca(2+))-activated K(+) channel. Clotrimazole (CLT), an inhibitor of the Gardos ...