This is a prospective study to establish prediction models that map the refined Scoliosis Research Society 22-item (SRS-22r) onto EuroQoL-5 dimension 5-level (EQ-5D-5L) utility scores in adolescent idiopathic scoliosis (AIS) patients. Comparison of treatment outcomes in AIS can be determined by cost-utility analysis. However, the mainstay spine-specific health-related quality of life outcome me...

The aim of this study was to examine the effects of 22R-hydroxycholesterol (22R-HC), folliclestimulating hormone (FSH) and luteinizing hormone (LH) on estradiol and progesterone production by cat granulosa cells. Granulosa cells from follicles were collected and cultured for up to 5 days in 24 well plates containing Dulbecco’s Modified Eagle’s Medium (DMEM)/HAM F-12 supplemented with 10 M andro...

The anti-inflammatory effects of the new steroidal antedrug, 21-acetyloxy-9α-fluoro-11β-hydroxyl-3, 20-dioxo-1, 4-pregnadieno-[16α, 17α-d] isoxazoline (FP-ISO-21AC), on nitric oxide (NO) and interleukin 8 (IL-8) production, were investigated together with its parent steroid prednisolone (PRED). PRED is one of the anti-inflammatory steroids but has systemic side effects which limit the use of it...

A novel strain, HY-22R(T), was isolated from soil of a Euphrates poplar forest in Xinjiang, China. The cells were Gram-positive-staining, rod-shaped and motile by means of peritrichous flagella. Growth occurred at 10-37 degrees C (optimum 30 degrees C), at pH 7.0-8.0 (optimum pH 7.0) and with 0-1 % NaCl. A phylogenetic analysis based on 16S rRNA gene sequences revealed that strain HY-22R(T) was...

BACKGROUND The SRS-22r questionnaire is a well-accepted instrument used to measure health-related quality of life in patients with idiopathic scoliosis. No validated tool exists in Brazil for idiopathic scoliosis, and the use of the SRS-22r in non-English Laguage contries requires its transcultural adaptation. OBJECTIVE The objective of this study was to culturally adapt the translated Brazil...

PURPOSE To reveal the prevalence of low back pain (LBP) and association between LBP and patient-reported QOL outcomes (JOABPEQ and SRS-22r) in patients with adolescent idiopathic scoliosis (AIS) without corrective surgery. METHODS Ninety-eight female patients with AIS without corrective surgery who answered JOABPEQ, SRS-22r, and VAS for LBP were included. The scores of all subdomains in JOABP...

While effects of inhaled corticosteroids on serum markers of bone metabolism in normal and asthmatic subjects have been reported, there are little data on the direct effects of these corticosteroids on end-organs such as bone. The results presented here compare the effects of budesonide and its epimers (22S- and 22R-budesonide), fluticasone and dexamethasone on growth and differentiation of cul...