Aspartyl aminopeptidase (DNPEP) has been implicated in the control of angiotensin signaling and endosome trafficking, but its precise biologic roles remain incompletely defined. We performed a high-throughput screen of ∼25,000 small molecules to identify inhibitors of DNPEP for use as tools to study its biologic functions. Twenty-three confirmed hits inhibited DNPEPcatalyzed hydrolysis of angio...

Bronkopulmoner sekestrasyon nadir görülen konjenital damarsal malformasyondur. Besleyici arterin gösterilmesi tanıyı koydurmaktadır. Bu çalışmada bilgisayarlı tomografinin besleyici arteri ve drenaj veni göstermedeki etkinliği araştırılmıştır. 2003-2008 yılları arasında pulmoner sekestrasyon tanısı alan yaşları 5-49 arasında değişen sekiz hasta (altı erkek, iki kadın) incelendi. Bütün hastalara...

A survey on intestinal parasitic infections and some risk factors of infection (social, economic and behavioral) was conducted in suburban area at Simum subdistrict, Mueang district, Nakhon Ratchasima Province during the period of April 3rd to April 11th, 2007. A total of 214 stool samples, from 85 males and 129 females were examined using simple direct smear, Kato’s thick smear and modified Ha...

The neural crest is a stem/progenitor cell population that contributes to a wide variety of derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and pigment cells of the skin. Unique to vertebrate embryos, it has served as an excellent model system for the study of cell behavior and identity owing to its multipotency, motility and ability to form a broad array of...

Nearly all the star clusters with ages of ∼1-2 Gyr in both Magellanic Clouds exhibit an extended main-sequence turn off (eMSTO) whose origin is under debate. The main scenarios suggest that the eMSTO could be either due to multiple generations of stars with different ages or to coeval stellar populations with different rotation rates. In this paper we use Hubble-Space-Telescope images to invest...

In the last years, large effort has been done to carry out multi-channel seismic reflection surveys (MCS) in SW Iberia to locate the active tectonic structures that could be related to the generation of the 1755 Lisbon earthquake and the tsunami. The outcome of these researches led to the identification of a large, compressive tectonic structure, named Marquês de Pombal thrust that, alone can a...