Cytochrome P450 (P450) enzymes play a critical role in the activation and detoxication of many neurotoxic chemicals. Although research has largely focused on P450-mediatedmetabolism in the liver, emerging evidence suggests that brain P450s influence neurotoxicity by modulating local metabolite levels. As a first step toward better understanding the relative role of brain P450s in determining ne...

Cytochrome P450 (P450) enzymes play a critical role in the activation and detoxication of many neurotoxic chemicals. Although research has largely focused on P450-mediatedmetabolism in the liver, emerging evidence suggests that brain P450s influence neurotoxicity by modulating local metabolite levels. As a first step toward better understanding the relative role of brain P450s in determining ne...

This paper presents an alternative method to data knowledge representation by using fuzzy conditional statements. The main idea of the proposed methodology is to group together load data in flexible structures which can then be used by conventional or intelligent programs, as well as by power system operators directly. In the paper, the algorithm to obtain the fuzzy conditional statements is pr...

Ethanol levels reached in circulation during moderate-to-heavy alcohol intoxication (50–100 mM) modify Caand voltagegated K (BK) channel steady-state activity, eventually altering both physiology and behavior. Ethanol action on BK steadystate activity solely requires the channel-forming subunit slo1 within a bare lipid environment. To identify the protein regions that confer ethanol sensitivity...

Driven by foreign investment, tourism in the archipelago of Zanzibar has experienced substantial growth over the last thirty years. Even though it was meant to promote local employment and economic development, foreigners – and Europeans in particular – remained the largest investors as well as the primary benefi ciaries. Tourism development has created new employment opportunities, but it has ...

3-Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for isoprenoid biosynthesis and serves as an alternative target for cholesterol-lowering and antibiotic drugs. We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl...

The biosynthesis of antibiotic 1233A (F-244) was studied by feeding 13C-labeled precursors to the producing organism, Scopulariopsis sp. F-244. 13C NMR spectroscopy established that 1233A is derived from 4 methionines and 7 acetates. Seven acetates are condensed to form a hexaketide and 4 methyl residues from methionine are introduced into the main skeleton. The beta-lactone is derived from the...

Th e publication of scientifi c literature and textbooks is probably one of the last stages in the development of a serious and mature university. Th is does not mean that universities after this phase do not continue to develop further, but rather that this phase is the completion of the internal structure. Th is is probably because publishing is a mature and developed academic activity associ...