Type 2 diabetic mellitus (DM2) is associated with accelerated thrombotic complications and is characterized by high levels of plasminogen activator inhibitor-1 (PAI-1). Recent studies show that human platelets have high levels of miR-30c and synthesize considerable active PAI-1. The underlying mechanism of how PAI-1 expression is upregulated in DM2 is poorly understood. We now report that hyper...

The cellular hypoxia-reoxygenation (H/R) model is an ideal method to study ischemia-reperfusion injury, which is associated with high mortality. The role of microRNA-30c-5p (miR-30c-5p) in the H/R epithelial cell model remains unknown. In the current study, we observed a significant reduction in apoptosis when miR-30c-5p was up-regulated. We also found decreased levels of C-caspase-3 (C-CASP3) ...

It is well known that microRNAs (miRNAs) play important roles in cancer development by targeting oncogenes or tumor-suppressor genes. However, little is known regarding the mechanisms of miR-30c action in endometrial cancer. In this study, we aimed to determine whether miR-30c targets metastasis-associated gene-1 (MTA1) and acts as a tumor suppres...

Systemic sclerosis (SSc) is characterized by peripheral circulatory disturbance and fibrosis in skin visceral organs. We recently demonstrated that ?2-antiplasmin (?2AP) elevated SSc dermal fibroblasts model mice, associated with progression vascular dysfunction. In the present study, we predicted ?2AP could be a target of microRNA-30c (miR-30c) using TargetScan online database, investigated ef...

miR-30c has been reported to act as a tumor suppressor and negatively regulate cancer metastasis by directly targeting metastasis associated genes; however, miR-30c has also been shown to promote the invasion of metastatic breast cancer cells, suggesting that miR-30c might be involved in cancer cell metastasis in different ways via targeting different genes. In this study, we demonstrated that ...

Aneurysmal subarachnoid hemorrhage is a severe neurological disease that characterized by acute onset, multiple complications and poor prognosis. The aim of this study was to analyze the relationship between expression level micro ribonucleic acid-30c in plasma prognosis patients with aneurysmal hemorrhage. A total 181 were prospectively selected as subjects. Modified Rankin scale used evaluate...

An experiment was carried out to study the effect of temperature on biology, oviposition and feeding behaviour as well as host preference of Epilachna beetle, Epilachna dodecastigma (Wied.) on eight varieties of brinjal, Solanum melongena Linn. from November, 2009 to June, 2010 maintaining controlled temperatures of 15oC, 25oC and 30oC using an incubator in the Department of Entomology, BAU, My...

MicroRNAs (miRNAs) are small noncoding RNAs that function as master regulators of posttranscriptional gene expression with each miRNA negatively regulating hundreds of genes. Lysophosphatidic acid (LPA) is a mitogenic lipid present within the ovarian tumor microenvironment and induces LPA receptor activation and intracellular signaling cascades like ERK/MAPK, leading to enhanced cellular prolif...

Microsomal triglyceride transfer protein (MTTP) is an essential chaperone that assists in the assembly of apolipoprotein B-containing lipoproteins to transport lipids. We have shown that microRNA (miR)-30c regulates MTTP expression but other members of the same family do not. Further, we showed that interactions between miR-30c seed sequence and the 3΄-untranslated region (UTR) of the MTTP mRNA...

The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML). We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a. Here, we confirm miR-30c as a novel important target of C/EBPα during granulopoiesis. Thus, wild-type C/EBPα-p42 ...