INTRODUCTION The specificity of the emergency medical act strongly manifests itself on account of a wide series of psycho-traumatizing factors augmented both by the vulnerable situation of the patient and the paroxysmal state of the act. Also, it has been recognized that the physical solicitation and distress levels are the highest among all medical specialties, this being a valuable marker for...

• The paper presents the data collection strategy of Swiss StudentLife Study. study investigated emergence undergraduate student communities. It combined multiple methods collection, including surveys and social sensors. Multidimensional dynamic networks were measured on different time scales. Practical challenges solutions are discussed to help future empirical studies. Study (SSL Study) is a ...

This review describes historical iodine deficiency in the UK, gives current information on dietary sources of iodine and summarises recent evidence of iodine deficiency and its association with child neurodevelopment. Iodine is required for the production of thyroid hormones that are needed for brain development, particularly during pregnancy. Iodine deficiency is a leading cause of preventable...

5-[(2-Chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4(4-pyrimidinyl)isoxazole (AKP-001) is a potent p38 mitogen-activated protein kinase inhibitor that is being developed to specifically target the intestines for the treatment of inflammatory bowel disease. According to the ante-drug concept, AKP-001 was designed to be metabolized to inactive forms via the first-pass metabolism to avoid...

contraceptives. Demographic surveys of contraceptive use in the United States typically have collected and reported data only on use of single methods; when more than one method is described by a respondent, the one reported by the investigator is usually the method that most effectively prevents pregnancy.4 Likewise, studies of HIV and STD risk often do not include data on contraceptive use fo...

Two clearly opposing views exist on the function of alpha-fetoprotein (AFP), a fetal plasma protein that binds estrogens with high affinity, in the sexual differentiation of the rodent brain. AFP has been proposed to either prevent the entry of estrogens or to actively transport estrogens into the developing female brain. The availability of Afp mutant mice (Afp–/–) now finally allows us to res...

In this work, we developed a microfluidic device for the imitation of drug metabolism in human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three sections: (1) bioreactors containing poly(ethylene) glycol (PEG) hydrogel encapsulated human liver microsomes (HLMs); (2) cell culture chambers for cytotoxicity assay; and (3) integrated micro solid-phase extract...

(800,000), syphilis (101,000)2 and trichomoniasis (three million).3 For viral STDs, however, there is no cure; these include human papilloma virus (between 500,000 and one million cases annually), genital herpes (200,000–500,000), sexually transmitted hepatitis B (53,000) and the human immunodeficiency virus, or HIV (which is responsible for 90,000 cases of AIDS annually).4 STDs other than HIV ...