Intrinsic deuterium-induced isotope effects have been measured and analyzed for compounds having one or two phenyl groups specifically labelled at different positions in a molecule. Some typical examples of directional and orientational dependence of the effects have been given. Different magnitudes of isotope effects that are transmitted in opposite directions have been observed. Thus, in p-2H...

A series of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives (4a-g) were prepared using a convenient and general one-pot procedure and evaluated for their in vitro antibacterial and antifungal activities by using the microdilution method in comparison with ampicillin and fluconazole. 3-Phenyl-5-(1-phenylethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione (4a) and 3p...

Introduction: The utility of estimates of glomerular filtration rate based on creatinine and cystatin C serum levels to assess renal function in older surgical patients remains to be determined. Objective: To determine whether 2h-creatinine clearance (CrCl-2h) can be an adequate substitute for glomerular filtration rate estimates obtained by measuring serum cystatin C and creatinine in the elde...

(a) Define a linear mapping R2h h : R 5 → R3 according to the full weighting scheme (see Lecture slides). Setup the respective matrix R2h h . (b) Define a linear mapping Ph 2h : R 3 → R5 which prolongates a solution vector from the coarse to the fine grid using linear interpolation (see Lecture slides). Setup the respective matrix Ph 2h. (c) Based on the matrices R2h h , P h 2h and Ah, compute ...

The stem and leaves of Gasteria bicolor afforded three new dihydroanthracenones namely 3,4-dihydro-2,6,9-trihydroxy-8-methyl-1(2H)-anthracenone (gasteriacenone A), 3,4-dihydro-2,4,9-trihydroxy-6-methoxy-8-methyl-1(2H)-anthracenone (gasteriacenone B) and 3,4-dihydro-4,6,9-trihydroxy-7-carbomethoxy-8-methyl-1(2H)-anthraceno ne (gasteriacenone C). Their structures were determined by spectroscopic ...

New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one, 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one, 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide, 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one were prepared starting...

(+)-2,5-Bis[4’-((S)-2-methyl butyoxy)phenyl]toluene (3a): 0.048 mol (10 g) 4-[(S)-2-methyl butoxyl]phenylboronic acid dissolved in 20 ml of ethanol is added dropwise to the mixture of 0.02 mol (5 g) of 2,5-dibromotoluene, 0.8 mmol (0.924 g) tetrakis(triphenylphosphine)palladium Suzuki cross-coupling catalyst, 20 ml of benzene, 40 ml of ethanol, and 60 ml of 2M Na2CO3 aqueous solution under argo...

Trehazolin (1) is a trehalase inhibitor produced by Micromonospora coriacea. Biosynthesis of 1 was studied by feeding experiments with a variety of labeled precursors. Feeding experiments with [1-13C]- and [6-13C]-D-glucose revealed that the carbon skeletons of both a glucose residue and a cyclopentane ring moiety in 1 were each derived from glucose, and that C-C bond formation between C-1 and ...

We report a detailed study of electrical and thermal transport properties in 2H-M$_x$TaS$_2$ (M = Mn, Co) magnets where M atoms are intercalated the van der Waals gap. The intercalation induces ferromagentism with an easy-plane anisotropy 2H-Mn$_x$TaS$_2$, but ferromagnetism strong uniaxial 2H-Co$_{0.22}$TaS$_2$, which finally evolves into three-dimensional antiferromagnetism 2H-Co$_{0.34}$TaS$...