Dihydropyrimidine and amidoalkyl naphthol derivatives have been prepared efficiently in a one-pot synthesis using ZnCl2/urea and ZnCl2/acetamide deep eutectic systems as reaction medium and homogeneous catalyst. This method offers some advantages such as simple procedure, inexpensive solvent and catalyst and good yields of the final products in short reaction times. The use of non-toxic and env...

portant molecules, pyrimidine has played an important role in medicinal chemistry. A survey of literature has shown that compounds having a pyrimidine nucleus possess a broad range of biological activities such as anticancer (1), antiviral (2), antibacterial (3), antimalarial (4), antihypertensive (5) and anti-inflammmatory activities (6, 7). Moreover, chemistry and synthesis of 1,2,3,4-tetrahy...

Montmorillonite modified is an efficient environmental friendly catalyst under one-pot-three-component synthesis of 3,4-dihydropyrimidine-2(1H) ones. The preparation was performed with an aldehyde, 1,3-dicarbonyl compounds, urea or thiourea under solvent-free conditions. In comparison with the other methods of Biginelli reaction, this new method has short reaction time inexpensive catalyst and ...

In 1893, P. Biginelli reported the synthesis of functionalized 3, 4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde, urea, and ethyl acetoacetate. In the past decade, this long-neglected multicomponent reaction has experienced a remarkable revival, mainly due to the interesting pharmacological properties associated with this dihydropyrimidin...

We report herein the synthesis of new derivatives dihydropyrimidine on basis 2,4,6-trimetoxybenzaldehyde, which was further regioselectively oxidized in presence cerium ammonium nitrate (CAN) with formation 5-acetyl-6-methyl-4-(2,4,6-trimethoxyphenyl)pyrimidin-2(1H)-one. The structures both novel compounds were investigated by NMR, mass spectroscopy methods. structure compound 4 also X-ray sing...