c © 2009 by John von Neumann Institute for Computing Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher ment...

c © 2007 by John von Neumann Institute for Computing Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher ment...

Markedly increased circulating concentrations of pyridoxal-5'-phosphate (PLP) were found in each of 14 patients representing all clinical forms of hypophosphatasia, an inborn error characterized by deficient activity of the tissue nonspecific (bone/liver/kidney) isoenzyme of alkaline phosphatase (AP). The mean PLP concentration in plasma was 1174 nM (range, 214-3839 nM) in the patients and 57 +...

The oxy-myoglobin (Mb-O2) structure was probed by QM/MM (hybrid quantum mechanical/ molecular mechanical) calculations using DFT/MM to elucidate the effect of the heme propionates and the protein matrix on the chemistry of heme Fe-O2 moiety. On this line, we have probed the role of His97 in various protonation states of the heme propionate-6.

Abstract Background and Aims Patients with systemic lupus erythematosus (SLE) are at an increased risk of developing nephritis (LN), which results in high morbidity mortality. There is preliminary data showing the efficacy low dose Arsenic Trioxide (ATO) reducing renal flares amongst LN patients, but underlying mechanism for such benefit remains unclear. Method We performed bioinformatic analys...

The well-established dissociation between the ventral object and dorsal spatial processing streams within the visual system suggests a contrast between object and spatial visual cognitive styles. We assessed the validity of this distinction using a self-report questionnaire in a sample of 3839 online participants, and laboratory cognitive tests in a subsample of 196. We found that (1) object an...

Spectral properties of sign symmetric matrices are studied. A criterion for sign symmetry of shifted basic circulant permutation matrices is proven, and is then used to answer the question which complex numbers can serve as eigenvalues of sign symmetric 3 × 3 matrices. The results are applied in the discussion of the eigenvalues of QM -matrices. In particular, it is shown that for every positiv...

We consider classes of models related to those introduced by Lehmann in 1953 and Sklar in 1959. Recently developed algorithms for finding profile NP likelihood procedures are discussed, extended and implemented for such models by combining them with the MM algorithm. In particular we consider statistical procedures for a regression model with proportional expected hazard rates, and for transfor...

Gravity models are widely used to explain patterns of trade. However, two stylized features of trade data, sample selection and heteroskedasticity, challenge the estimation of gravity models. We propose a Two-Step Method of Moments (TS-MM) estimator that deals with both issues. The Monte-Carlo experiments show that the TS-MM estimates are resistant to various combinations of sample selection an...