The title compound, [Pb(2)Zn(2)(C(22)H(18)N(2)O(4))(2)Cl(4)]·2C(3)H(7)NO, was synthesized using a step-by-step method and has a slipped sandwich configuration. The coordination environment of the Zn(2+) ion is distorted square-pyramidal and it is coordinated by N(2)O(2) of the Schiff base ligand and chloride; each Pb(2+) ion is coordinated by the four 6,6'-dimeth-oxy-2,2'-[o-phenyl-ene-bis(nitr...

Dwyer, Terry M., and Jerry M. Farley. Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells. Am J Physiol Lung Cell Mol Physiol 278: L675–L682, 2000.—Neutrophil elastase can contribute to the pathogenesis of increased airway reactivity and excess mucus secretion in many pulmonary diseases. Ten nanomolar human neutrophil elastase (HNE) effe...

MARGA OORTGIESEN,1 BELLINA VERONESI,2 GARY EICHENBAUM,3 PATRICK F. KISER,3 AND SIDNEY A. SIMON1 1Departments of Anesthesiology and Neurobiology and 3Department of Mechanical Engineering and Materials Sciences, Duke University Medical Center, Durham 27710; and 2Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, ...

Lazrak, A., A. Samanta, and S. Matalon. Biophysical properties and molecular characterization of amiloridesensitive sodium channels in A549 cells. Am J Physiol Lung Cell Mol Physiol 278: L848–L857, 2000.—Amiloride-sensitive Na1 channels, present in fetal and adult alveolar epithelial type II (ATII) cells, play a critical role in the reabsorption of fetal fluid shortly after birth and in limitin...

KRISTIINA JÄRVINEN,1 PETRA PIETARINEN-RUNTTI,1 KAIJA LINNAINMAA,2 KARI O. RAIVIO,1 CECILE M. KREJSA,3 TERRANCE KAVANAGH,3 AND VUOKKO L. KINNULA4 1Childrens Hospital, University of Helsinki, 00029 Helsinki; 2Finnish Institute of Occupational Health, 00250 Helsinki; 4Department of Internal Medicine, University of Oulu, 90220 Oulu Finland; and 3Department of Environmental Health, University of Was...

Carraway, Martha Sue, Andrew J. Ghio, Jacqueline D. Carter, and Claude A. Piantadosi. Expression of heme oxygenase-1 in the lung in chronic hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L806–L812, 2000.—Heme oxygenase (HO)-1 is an oxygen-dependent enzyme that may regulate vascular tone and cell proliferation through the production of carbon monoxide (CO). We tested the hypothesis that ...

Borron, Paul, J. Clarke McIntosh, Thomas R. Korfhagen, Jeffrey A. Whitsett, Julie Taylor, and Jo Rae Wright. Surfactant-associated protein A inhibits LPSinduced cytokine and nitric oxide production in vivo. Am J Physiol Lung Cell Mol Physiol 278: L840–L847, 2000.—The role of surfactant-associated protein (SP) A in the mediation of pulmonary responses to bacterial lipopolysaccharide (LPS) was as...

Studies have suggested that plasma lead levels may better reflect the toxicologically labile fraction of circulatory Pb that is more freely available for exchange with target tissues than do Pb levels in whole blood. Studies have also reported an apparent severalfold variation in the relative partitioning of Pb between whole blood and plasma (or serum) for a given whole-blood Pb level. This may...

We evaluate air Pb emissions and latent aggravated assault behavior at the scale of the city. We accomplish this by regressing annual Federal Bureau of Investigation aggravated assault rate records against the rise and fall of annual vehicle Pb emissions in Chicago (Illinois), Indianapolis (Indiana), Minneapolis (Minnesota), San Diego (California), Atlanta (Georgia), and New Orleans (Louisiana)...