نتایج جستجو برای: 432 سال
تعداد نتایج: 162138 فیلتر نتایج به سال:
OK-432 (Picibanil), a streptococcal preparation with potent biological response modifying activities, was approved in Japan as an anticancer agent in 1975. In the ensuing 30 years, since then, a significant amount of data, including clinical as well as experimental studies, has been accumulated. OK-432 has been reported to induce various cytokines, activate immunological cells and thus augment ...
Circulation. 2016;134:432–434. DOI: 10.1161/CIRCULATIONAHA.116.022803 432
OBJECTIVE To report the experience with OK-432 therapy for lymphangioma in children. METHODS Retrospective study of 19 children with lymphangioma treated with OK-432 in Ribeirão Preto, state of São Paulo, Brazil, between 1999 and 2003. RESULTS All patients presented response to OK-432, 12 had total shrinkage and seven had partial shrinkage varying from 50 to 80%. Patients had fever after in...
Cancer immunotherapy using dendritic cells (DCs) adenovirally transduced with the whole tumor-associated antigen (TAA) gene is an effective approach. Streptococcal preparation OK-432 is useful for stimulating DCs in terms of maturation. In this study, we established carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes (CTLs) using in vitro stimulation with adenovirally modified human...
Purpose: This study aims to evaluate the effectiveness of OK-432 immunotherapy in the treatment of lymphatic malformation (LM) in children and to determine its complications and contraindications. Methods: Twenty-eight patients with LM of head and neck were enrolled. Twenty-three (82.2%) patients were treated with OK-432 immunotherapy, and surgery was performed in 5 (17.8%). LMs were classified...
Abnormal proliferation and drug resistance are the hallmarks of lung adenocarcinoma (LAD). Dispite the advances in diagnosis and therapy, the 5-year survival remains low. Increasing studies regarding its pathological mechanism have been focused on microRNA (miRNA) due to its nodal regulatory properties. This study aims to characterize the expression of miR-432 in LAD and investigate its effects...
Polymorphisms within genes responsible for estrogen catabolism could alter cellular levels of genotoxic 4-hydroxylated catechol estrogens and antiangiogenic 2-methoxyestradiol, thus influencing risk of developing ovarian cancer. We carried out a population-based case-control study of 310 epithelial ovarian cancer cases and 585 controls in African-American and Caucasian women ages 35 to 54 years...
OK-432 (picibanil) is an inactivated preparation of Streptococcus pyogenes that causes pleurodesis by inducing a strong inflammatory response. Intrapleural instillation of OK-432 has recently been used to successfully treat neonatal and fetal chylothorax. Here we report a trial of intrapleural instillation of OK-432 in two preterm infants who were born with hydrops fetalis and massive bilateral...
To clarify the effect of large dose intratumoral administration of OK-432, experimental and clinical investigations were perfonned. In the experimental study, 250 KE/Kg OK-432 was administered into S-180 sarcoma in ddN mice. Mice treated by OK-432 showed significant increase in delayed hypersensitivity reaction and elongation in the survival times. In the clinical study, 50 KE OK-432 was inject...
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