Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene (DMD), and is characterized by progressive weakness inskeletal andcardiacmuscles.Currently, dilatedcardiomyopathydue to cardiac muscle loss is one of the major causes of lethality in late-stage DMD patients. To study the molecular mechanisms underlying dilated cardiomyopathy in DMD heart, we generated cardiomyocytes...

Recruitment of intertidal barnacles was markedly higher in May–September 1997, just after the apparent onset of El Niño conditions in the waters off California, than over the same period during the previous year. This increase was geographically broad, spanning five degrees of latitude, and was unusually large, relative to interannual differences in barnacle recruitment previously documented fo...

We describe a method, DNA array to protein array (DAPA), which allows the ‘printing’ of replicate protein arrays directly from a DNA array template using cell-free protein synthesis. At least 20 copies of a protein array can be obtained from a single DNA array. DAPA eliminates the need for separate protein expression, purification and spotting, and also overcomes the problem of long-term functi...

Volume 30, Number 4, July/August 1998 play an important role in teenage pregnancy. The U.S. Congress made the prevention of teenage pregnancies a major objective of the 1996 federal welfare reform law,3 which recommends that “the states and local jurisdictions should aggressively enforce statutory rape laws” as one way to achieve this end.4 As a result, states are reconsidering both the content...

The goal of this brief review is to address the role of the ageing gut in the genesis of malnutrition in the elderly. We assess the burden of malnutrition in the elderly, exploring the role of comorbid conditions and neurohumoral changes that take place to contribute towards the process of anorexia associated with ageing. Following this, the review assesses physiological changes that occur in e...

Loss of chromosome 1p/19q in oligodendrogliomas represents a powerful predictor of good prognosis. Expression of internexin (INA), a neuronal specific intermediate filament protein, has recently been proposed as a surrogate marker for 1p/19q deletion based on the high degree of correlation between both parameters in oligodendrogliomas. The aim of this study was to assess further the diagnostic ...

Trends in Abortion Attitudes The GSS has carefully maintained the same wording and sequence of questions from year to year to avoid introducing context changes into the time series.* Respondents are asked whether a woman should be able to obtain a legal abortion for a series of reasons, beginning with “if there is a strong chance of defect in the baby” and ending with “if the woman wants it for...