Purpose: Gain-of-function mutations and KIT overexpression are well-known tumorigenesis mechanisms in gastrointestinal stromal tumors (GISTs). This study aimed to discover microRNAs that target KIT and reveal the relationship between the discovered microRNAs and KIT expression in GISTs. Experimental Design: Fresh-frozen GISTs from 31 patients were used to confirm the relationship between miR-49...

487 HISTORY OF INTERVIEWING 488 PURPOSE OF ASSESSMENT INTERVIEWS 488 TYPES OF INTERVIEWS 488 Case History Interviews 489 Diagnostic Interviews 489 Follow-Up Interviews 489 Forensic Interviews 489 Intake Interviews 490 Interviewing for Etiology 490 Mental Status Exams 490 Orientation Interviews 490 Preand Posttesting Interviews 490 Screening Interviews 491 Specialized Interviews 491 Termination ...

PURPOSE Gain-of-function mutations and KIT overexpression are well-known tumorigenesis mechanisms in gastrointestinal stromal tumors (GIST). This study aimed to discover microRNAs (miRNA) that target KIT and reveal the relationship between the discovered miRNAs and KIT expression in GISTs. EXPERIMENTAL DESIGN Fresh-frozen GISTs from 31 patients were used to confirm the relationship between mi...

MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the associ...

In neural integrators, transient inputs are accumulated into persistent firing rates that are a neural correlate of short-term memory. Integrators often contain two opposing cell populations that increase and decrease sustained firing as a stored parameter value rises. A leading hypothesis for the mechanism of persistence is positive feedback through mutual inhibition between these opposing pop...

MicroRNA (miRNA) is involved in the progression and metastasis of diverse human cancers, including breast cancer, as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. Here, we show that miR-494 is decreased in human breast cancer specimens and breast cancer cell lines. Ectopic expression of miR-494 in basal-like breast cancer cell lines MDA-MB-231-LUC-D2...

sulfur utilizing autotrophic denitrification synthetic wastewater in up flow packed --bed reactor was evaluated under different concentrations of alkalinity and organic matter. the reactor was filled with granular elemental sulfur particles with diameters of 2.8-5.6 mm and porosity of 40%. the initial culture was prepared from sludge of shahrak ghods wastewater treatment plant. first, the stoic...

Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications characterized by insulin resistance and pancreatic β-cell dysfunction. Increasing evidence suggests that microRNAs (miRNAs) play key roles in the diverse types of diabetes, including GDM. However, the underlying mechanisms remain largely unknown. The purpose of this study is to investigate the role of microRNA...

Gene L Bowman1† & Joseph F Quinn2 †Author for correspondence 1Oregon Health & Science University, CR-131 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA Tel.: +1 503 494 6976; Fax: +1 503 494 7499; Email: [email protected] 2Oregon Health & Science University, Clinical Core, NIA-Layton Aging & Alzheimer’s Disease Center, OR, USA Tel.: +1 503 494 6976; Fax: +1 503 494 7499; Email: qu...

Chronic inflammation is fundamental for the induction of insulin resistance in the muscle tissue of vertebrates. Although several miRNAs are thought to be involved in the development of insulin resistance, the role of miRNAs in the association between inflammation and insulin resistance in muscle tissue is poorly understood. Herein, we investigated the aberrant expression of miRNAs by conductin...