نتایج جستجو برای: 5 and 5
تعداد نتایج: 17026982 فیلتر نتایج به سال:
The Ten-eleven translocation (TET) proteins have been recently identified as critical regulators in epigenetic modification, especially in the methylation of cytosine in DNA. TET-mediated DNA oxidation plays prominent roles in a wide variety of physiological and pathological processes, especially in tumor and neural development. TET proteins execute stepwise enzymatic conversion of 5-methylcyto...
We present a chemical method to selectively tag and enrich thymine modifications, 5-formyluracil (5-fU) and 5-hydroxymethyluracil (5-hmU), found naturally in DNA. Inherent reactivity differences have enabled us to tag 5-fU chemoselectively over its C modification counterpart, 5-formylcytosine (5-fC). We rationalized the enhanced reactivity of 5-fU compared to 5-fC via ab initio quantum mechanic...
several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-fu related toxicity. the aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-fu in rabbits, mice and dogs. it was further aimed to determine its route related toxicity in rabbits. plasma concentration of both 5-fu and its metabolite 5-f...
5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve t...
The absolute levels of 5-hydroxymethylcytosine (hmC) and 5-methylcytosine (mC) in human brain tissues at various ages were determined. Additionally, absolute levels of 5-formylcytosine (fC) in adult individuals and cytosine modification levels in sorted neurons were quantified. These data were compared with age-related fC, hmC, and mC levels in mouse brain samples. For hmC, an initial steady in...
این پژوهش با هدف کلی مطالعه انطباق ساختار پنج عاملی شخصیت مرضی (PSY-5) با محور دوم DSM-5 در قالب یک پژوهش پیمایشی پرسشنامهای انجام گرفته است. پژوهش از جمله مطالعات روششناسی و آزمونسازی به حساب میآید. در این تحقیق ابتدا حمایت تجربی دادههای ایرانی برای ساختار پنج عاملی شخصیت مرضی (PSY-5) و ساختار عاملی صفات و حیطههای کلی شخصیت DSM-5 مطالعه شدند. سپس همخوانی بین مقیاسهای شخصیت مرضی (PSY-5) ...
The fifth paper of reviews on COVID-19 addresses COVID-19 vaccines, as vaccination has started in the world and Iran. In this paper, we review different types of available vaccines and also various platforms for production of COVID-19 vaccines as well as the vaccines produced in each platform in the world and Iran. Then the considerations about vaccination in patients with skin diseases, specia...
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