يتضمن البحث تحضَير عدد من مشتقات6-bromo-2-phenylquinoline-4-carboxylic acid ، وقد تم تشخيصها بوساطة قياس درجة الانصهار والتحليل الكمي الدقيق للعناصر (C.H.N.S) وطيف الرنين النووي المغناطيسي للبروتون (1H-NMR) و تحليل طيف الأشعة تحت الحمراء (FT-IR) . ومن المركبات المحضرة
 1-تحضير المركب [A1] 6-bromo-2-phenylquinoline-4-carboxylic acid
 2-تحضير 6-bromo-2-phenylquinoline-4-carboxyl chloride...

The present studies were designed to synthesize the three disulfide derivatives bearing S-S bond formation, their characterization and explore antibacterial activity using in silico analysis. They synthesized by condensation reaction of 2-(2-(2-aminophenyl) disulfanyl) benzeneamine with 3-bromo-2-hydroxy-5-nitrobenzaldehyde; 5-bromo-2-hydroxybenzaldehyde 3, 5-dichloro-2-hydroxy-benzaldehyde, re...

The title compound, C(25)H(24)N(2)O(3) was prepared by the reaction of (Z)-2-(1H-indol-3-ylmethyl-ene)-1-aza-bicyclo-[2.2.2]octan-3-one with methyl p-(bromo-meth-yl)benzoate, under phase-transfer catalytic (PTC) conditions using triethyl-benzyl-ammonium chloride and 50% w/v aqueous NaOH solution in dichloro-methane. The crystal structure indicates the presence of a double bond with Z geometry c...

The title compound, C(8)H(8)BrNO(2), does not show any significant inter-molecular π-π or C-H⋯π inter-actions in the crystal packing except for one weak Br⋯Br [3.715 (1) Å] inter-action.

The title compound, C(24)H(21)N(3)O, was prepared by the reaction of (Z)-2-(1H-indol-3-ylmethyl-ene)-1-aza-bicyclo-[2.2.2]octan-3-one with α-bromo-p-toluonitrile, under phase-transfer catalytic (PTC) conditions using triethyl-benzyl-ammonium chloride and 50% w/v aqueous NaOH solution in dichloro-methane. The crystal structure indicates the presence of a double bond with Z geometry connecting th...

The asymmetric unit of the title salt, K(+)·C(6)H(3)BrCl(2)NO(2)S(-)·1.5H(2)O, contains one K(+) cation, one N-bromo-2,4-dichlorobenzenesulfonamidate anion, one water molecule in general position and one water molecule located on a twofold rotation axis. The K(+) cation is hepta-coordinated by three water O atoms and four sulfonyl O atoms from three symmetry-related N-bromo-2,4-dichloro-benzene...

2-Methyl-8-quinolinol and sixteen 5-, 7-, and 5,7-substituted derivatives with fluoro, chloro, bromo, iodo, nitro, and amino substituents were tested for in vitro antifungal activity against five fungi, Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes. The 5,7-dichloro and 5,7-dibromo derivatives were the most fungitoxic of the compounds ...

In this study, three methods are utilized to analyze toxicity produced by methotrexate and the lipid-soluble antifolate, 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine, in human lymphoblasts (WIL-2) and leukemic cells. These methods detect increasingly severe metabolic damage; inhibition of deoxyuridine incorporation into DNA, the reversibility of inhibition of deoxyuridine incorporati...