http://www.sciencemag.org/cgi/content/full/299/5607/682 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/299/5607/682/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...

BACKGROUND The pathogenesis of Alzheimer's disease is attributed to misfolding of Amyloid-β (Aβ) peptides. Aβ is generated during amyloidogenic processing of Aβ-precursor protein (APP). Another characteristic of the AD brain is increased phosphorylation of APP amino acid Tyr(682). Tyr(682) is part of the Y(682)ENPTY(687) motif, a docking site for interaction with cytosolic proteins that regulat...

http://www.sciencemag.org/cgi/content/full/299/5607/682 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/299/5607/682/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...

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The protein phosphatase inhibitor RK-682 is one of a number of potentially valuable tetronate polyketide natural products. Understanding how the tetronate ring is formed has been frustrated by the inaccessibility of the putative substrates. We report the heterologous expression of rk genes in Saccharopolyspora erythraea and reconstitution of the RK-682 pathway using recombinant enzymes, and we ...

Statistical Significance of Bio Monitoring of Marine Algae for Trace Metal Levels in a Coral Environment Anu Gopinath, Nair S. Muraleedharan, Chandramohanakumar N. and Jayalakshmi K.V. 1 Department of Chemistry, St. Teresa’s College, Cochin – 682 011, India 2 Department of Chemical Oceanography, School of Marine Sciences, Cochin University of Science and Technology, Cochin – 682 016, India. 3 N...

Previous investigations have determined that some individuals have minimal or even ergolytic performance effects after caffeine ingestion. The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate dose of caffeine. In a double-blind randomized experimental design, 21 healthy active participants ...

http://bmj.com/cgi/content/full/336/7643/518 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/336/7643/518#BIBL This article cites 4 articles, 1 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/336/7643/518 You can respond to this article at: http://bmj.com/cgi/content/full/336/7643/518#responses free ...