نتایج جستجو برای: 537
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Methotrexate (MTX) is the cornerstone of chemotherapy for primary central nervous system lymphoma, yet how the bloodbrain barrier (BBB) efflux transporters ABCG2 and ABCC4 influence the required high-dose therapy is unknown. To evaluate their role, we used four mouse strains, C57BL/6 (wild-type; WT), Abcg2, Abcc4, and Abcg2;Abcc4 (double knockout; DKO) to conduct brain microdialysis studies aft...
Cancer has been attributed to 3 causes: pollution, infection, and poor nutrition. Conventional treatments include surgery, chemotherapy, and radiotherapy. The author proposes that immunotherapy also be considered. Among other environmental influences, dietary deficiencies and carcinogenic viral infections must be investigated and treated wherever possible. It has been suggested that mushrooms, ...
Biosynthesis of coenzyme A (CoA) requires a five-step process using pantothenate and cysteine in the fission yeast Schizosaccharomyces pombe. CoA contains a thiol (SH) group, which reacts with carboxylic acid to form thioesters, giving rise to acyl-activated CoAs such as acetyl-CoA. Acetyl-CoA is essential for energy metabolism and protein acetylation, and, in higher eukaryotes, for the product...
Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka 537-0025; Osaka Prefectural Dog Management Office, Osaka 537-0025; Food Safety Promotion Division, Department of Public Health and Welfare, Osaka Prefectural Government, Osaka 540-8570; and Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo 208-0011, J...
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