نتایج جستجو برای: 551 inhabitants
تعداد نتایج: 13779 فیلتر نتایج به سال:
BACKGROUND Systemic sclerosis (SSc) is a clinically heterogeneous, life-threatening disease characterized by fibrosis, microvasculopathy, and autoimmunity. Extensive nonclinical and clinical data implicate B cells in the pathogenesis of SSc. MEDI-551 is an investigational humanized monoclonal antibody that targets the B cell surface antigen CD19 and mediates antibody-dependent, cell-mediated cy...
The first issue is whether one ought to use of Bayesian or Classical methods of inference. I will briefly cover Bayesian methods which have been revitalized given recent developments in monte carlo simulation and numerical integration. Nevertheless, Bayesian methods are still computationally burdensome and heavily linked to particular parametric functional forms, limiting their applicability to...
Through dedication and intelligent research, Haldor Topsøe’s name has become synonymous with efficient and profitable ammonia production and has set the standard for ammonia catalysts and technology. We build upon this legacy with the introduction of an ammonia synthesis catalyst that delivers the highest performance ever – KM 111. KM 111 is a magnetite-based catalyst developed for optimal perf...
MS-551 is a newly synthesized, nonspecific K+ channel blocker. To elucidate its electrophysiological and potential proarrhythmic effects relative to those of dl-sotalol in vivo, serial changes in ECGs, endocardial and epicardial monophasic action potential durations, and left and right ventricular pressures were measured simultaneously in pentobarbital-anesthetized open-chest dogs. Complete hea...
The pan B-cell surface antigen CD19 is an attractive target for therapeutic monoclonal antibody (mAb) approaches. We have generated a new afucosylated anti-human (hu)CD19 mAb, MEDI-551, with increased affinity to human FcγRIIIA and mouse FcγRIV and enhanced antibody-dependent cellular cytotoxicity (ADCC). During in vitro ADCC assays with B-cell lines, MEDI-551 is effective at much lower mAb con...
We demonstrate that the cccB gene, identified in the Bacillus subtilis genome sequence project, is the structural gene for a 10-kDa membrane-bound cytochrome c(551) lipoprotein described for the first time in B. subtilis. Apparently, CccB corresponds to cytochrome c(551) of the thermophilic bacterium Bacillus PS3. The heme domain of B. subtilis cytochrome c(551) is very similar to that of cytoc...
OBJECTIVE The frequency-dependent effects of MS-551 on the action potential duration (APD) and the underlying ionic mechanisms were investigated in comparison with those of E-4031. METHODS Whole-cell clamp techniques were used to study action potentials and ionic currents in enzymatically isolated rabbit ventricular myocytes. RESULTS The frequency-response obtained within the range of 0.1 t...
Type IIA and IIB von Willebrand disease (vWD) result from qualitative abnormalities of von Willebrand factor (vWF) characterized by an absence in plasma of high molecular weight vWF multimers and an abnormal reactivity of vWF towards platelet glycoprotein (GP) Ib, which is decreased in type IIA and increased in type IIB. In this report, we describe the case of a patient having a IIA vWD phenoty...
To meet Euro VI emission targets for heavy-duty applications, truck manufacturers concentrate on Exhaust Gas Recirculation (EGR) and its combination with urea-based Selective Catalytic Reduction (SCR). TNO developed a concept that opens the route for an alternative solution which relies on SCR as the main technology for NOx abatement. This concept offers potential fuel benefits in combination w...
Skin is the third most zinc (Zn)-abundant tissue in body, In skin, mast cell (MC) granules are enriched Zn. Cellular Zn levels strictly regulated by two groups of transporters: transporters (ZnTs) and Zrt-, Irt-like protein (ZIPs). ZnT expressions were previously determined bone-marrow derived MCs (BMMCs). contrast, little known about ZIP expressions. Thus, aim this study to determine murine MC...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید