In 2007, the Ontario Ministry of Health and Long-Term Care made an investment to support full-time employment for new graduate nurses. This paper describes the collaboration of policy makers and researchers in the creation and implementation of the Nursing Graduate Guarantee (NGG). We provide historical context for the development of the initiative and discuss some of the issues related to its ...

1 Bhattacharya AK, Lin DS, Connor WE. Cholestanol metabolism in patients with cerebrotendinous xanthomatosis: absorption, turnover and tissue deposition. J Lipid Res 2007; 48: 185–92 2 Cali JJ, Russell DW. Characterization of human sterol 27 hydroxylase: a mitochondrial cytochrome P-450 that catalyzes multiple oxidation reactions in bile acid biosynthesis. J Biol Chem 1991; 266: 7774–8 3 Cruysb...

Screens in mosaicDrosophila tissues that use chemical mutagenesis have identified many regulators of growth and patterning. Many of the mutant phenotypes observed were contingent upon the presence of both wild-type and mutant cells in the same tissue. More recently, large collections of RNAi lines or cDNAs expressed under Gal4/UAS control have been used to alter gene expression uniformly in spe...

The present study investigated whether peroxynitrite (ONOO)-elicited cytotoxicity on human brain vessel smooth muscle cells (HBVSMCs) was related to alteration in programmed cell death 4 (PDCD4) gene expression. Cell viability, morphological changes and apoptosis were determined by methylthiazoletetrazolium (MTT) assay, acridine orange staining and flow cytometry, respectively. Expressions of P...

1 Bhattacharya AK, Lin DS, Connor WE. Cholestanol metabolism in patients with cerebrotendinous xanthomatosis: absorption, turnover and tissue deposition. J Lipid Res 2007; 48: 185–92 2 Cali JJ, Russell DW. Characterization of human sterol 27 hydroxylase: a mitochondrial cytochrome P-450 that catalyzes multiple oxidation reactions in bile acid biosynthesis. J Biol Chem 1991; 266: 7774–8 3 Cruysb...

Genome-scale metabolic reconstructions are typically validated by comparing in silico growth predictions across different mutants utilizing different carbon sources with in vivo growth data. This comparison results in two types of model-prediction inconsistencies; either the model predicts growth when no growth is observed in the experiment (GNG inconsistencies) or the model predicts no growth ...

GRIDs technology has developed from first generation, supplier-specific and configurationspecific systems through second generation systems providing metacomputing facilities over various underlying platforms. The 2.5 generation added facilities for fast data transfer (GRIDFTP) and directories (LDAP). The third generation embraced from the W3C (World Wide Web Consortium) community the idea of s...

This study focuses on optimization and validation of an Ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous analysis of 11mycotoxins: Aflatoxin B1, T-2 Toxin, Ochratoxin A, Deoxynivalenol and Zearalenone in wheat matrix. Sample extraction and cleanup procedure is based on a single extraction step using acetonitrile/water/acetic acid mixture...

This study focuses on optimization and validation of an Ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous analysis of 11mycotoxins: Aflatoxin B1, T-2 Toxin, Ochratoxin A, Deoxynivalenol and Zearalenone in wheat matrix. Sample extraction and cleanup procedure is based on a single extraction step using acetonitrile/water/acetic acid mixture...

Bu araştırmanın amacı, otizm spektrum bozukluğu (OSB) tanılı ve normal gelişim gösteren (NGG) 9-12 yaş grubu çocuğa sahip annelerin çocuk yetiştirme tutumlarının incelenmesidir. Çalışma grubunu, 90 NGG 70 OSB’li çocuğu olan 160 anne oluşturmuştur. Verilerin toplanmasında Anne-Baba Tutum Ölçeği (ABTÖ)-C Formu kullanılmıştır. analizinde Kruskal Wallis-H Mann Whitney-U testlerinden yararlanılmıştı...