OBJECTIVE Several cutoff points of the homeostasis model assessment of insulin resistance (HOMA-IR; varying from 2.5 to 4.0) have been suggested for diagnosing IR in youth. In this study, we determined the distribution of the HOMA-IR in Mexican children and adolescents. DESIGN AND METHODS A total of 6132 children and adolescents from San Luis Potosi, León, Queretaro, and Durango, which are ci...

Using the homeostasis model assessment (HOMA) index, we investigated the link between insulin resistance and lifestyle in Japanese female university students. We used data for 57 Japanese female university students (21.0±0.8 years) who were enrolled in a cross-sectional investigation study. We performed full blood examinations, and anthropometric parameters, nutrient oral intake and daily step ...

The homeostasis model assessment (HOMA) is a method for assessing -cell function and insulin sensitivity that has gained widespread use thanks to its simplicity and validity (1). The method has recently been reviewed by the group of investigators that championed its development (2). They pointed out that -cell function cannot be interpreted without the knowledge of insulin sensitivity, and, thu...

BACKGROUND We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. METHODS Healthy men (n = 576, 30 ~ 79 years old) were genotyped for rs174537 near FADS1 (FEN1-10154G>T), FADS2 (rs174575C>G, rs2727270C>T), and FADS3 (rs1000778C...

The glucose level linkages with breast cancer (BC) biomarkers are focused in the article adopting probabilistic modeling a real data set surveyed from 64 BC women and 52 normal along 10 interested study factors. It is derived that mean levels over for (P=0.02224) than normal. Mean inversely linked insulin (P< 0.00001), interaction effects of leptin adiponectin (leptin*adiponectin) (P=0.08834...

BACKGROUND Drugs with unspecific stimulating effects on beta-cell secretion increase the homeostasis model assessment (HOMA)-B score, indicating improved beta-cell "function." We investigated whether the beta-cell protection provided by adding pioglitazone (PIO) to glimepiride (GLIM) in comparison to up-titrating the GLIM dose alone is reflected by appropriate changes in several measures of bet...

OBJECTIVE The link between plasma resistin and obesity-related cardiometabolic disorders in children remains debatable. This study assessed the relationships of plasma resistin with cardiovascular risk factors, pro-inflammatory markers and insulin resistance index (HOMA-IR) in obese (Ob) adolescents and obese adolescents with metabolic syndrome (Ob-MS) compared to healthy controls (CO). METHO...

Purpose: The objectives of the present study were to develop biochemical indices as a more practical way for early diagnosis cases with suspected metabolic dysfunction-assosiated steatotic liver disease (MASLD) and easy biomarkers enable clinicians recognize MASLD in obese children. 
 Materials Methods: A total 90 patients who had 70 healthy volunteering children between ages 6-18 diagnose...

The anxiety, depression, and stress, along with diabetes, obesity, lack of vital power, many other threats to human health, are the issues which humans have face in 21st century due modern bad lifestyles. Many medicines scientific experiments find solution new ways through pharma industries being sought. present manuscript not only deals aspects on these all afore said issues, but also scientif...