Caspase 8 (CASP8) is an apoptosis-related cysteine peptidase involved in the death receptor pathway and likely in the mitochondrial pathway. A CASP8 promoter region six-nucleotide deletion/insertion (-652 6N ins/del) variant and a coding region D302H polymorphism are reportedly important in cancer development, but no reported study has assessed the associations of these genetic variations with ...

OBJECTIVES To determine the antiviral activity, pharmacokinetics, pharmacodynamics, safety, and tolerability of several dose levels of oral TBR-652 monotherapy in HIV-1-infected, antiretroviral experienced, CCR5 antagonist-naive subjects. DESIGN Double-blind placebo-controlled study in the United States and Argentina. METHODS Subjects were randomized in a ratio of 4:1 per dose level to TBR-...

Caspase-8 (encoded by the CASP-8 gene) is crucial in generating cell death signals and eliminating potentially malignant cells. Genetic variation in CASP8 may affect susceptibility to cancer. The CASP-8 -652 6N ins/del (rs3834129) polymorphism has been previously reported to influence the progression to several cancers. However, the overall reported studies have shown inconsistent conclusions. ...

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PERSPECTIVES ANDUMMARY .............................................................. 632 HSP110 .................................................................................................. 634 THE HSP 90 FAMILY .............................................................................. 634 Biochemical Analysis ..............................................................................

A major goal in chemical kinetics is to determine the sequence of elementary reactions, or the reaction mechanism, that comprise complex reactions. For example, Sherwood Rowland and Mario Molina won the Nobel Prize in Chemistry in 1995 for proposing the elementary reactions involving chlorine radicals that contribute to the overall reaction of O3 → O2 in the troposphere. In the following sectio...

These include: References http://jech.bmjjournals.com/cgi/content/full/60/8/652#BIBL This article cites 8 articles, 2 of which can be accessed free at: Rapid responses http://jech.bmjjournals.com/cgi/eletter-submit/60/8/652 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign up in the box a...

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www.sciencemag.org (this information is current as of January 8, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/313/5787/652 version of this article at: including high-resolution figures, can be found in the online Updated information and services, found at: can be related to this article A list of selected additional a...