The Ashwell receptor, the major lectin of hepatocytes, rapidly clears from blood circulation glycoproteins bearing glycan ligands that include galactose and N-acetylgalactosamine. This asialoglycoprotein receptor activity remains a key factor in the development and administration of glycoprotein pharmaceuticals, yet a biological purpose of the Ashwell receptor has remained elusive. We have iden...

The method for reduction of the number of programmable array logic macrocells in a microprogrammed Moore finite state machine circuit is proposed. It is based on representation of the state code as a concatenation of a code for the class of pseudoequivalent states and a code of states inside this class. Such an approach allows eliminating the dependence between states and microoperations. The s...

BACKGROUND Increasing evidence suggests that microRNAs (miRNAs) play critical roles in malignant transformation, tumor progression and metastasis. Aberrant miR-655-3p expression has been associated with several cancers. However, the role and underlying mechanism of miR-655-3p in the development of hepatocellular carcinoma (HCC) remains unclear. METHODS MiR-655-3p expression was detected by qu...

The correlation between the expression level of microRNA (miR)-655 in esophageal cancer with proliferation, invasion and prognosis was investigated. Reverse transcription-quantitative polymerase chain reaction technique was used to detect the expression level of miR-655 in esophageal cancer cell lines KYSE410 and EC9706, tumor tissues and normal cancer-adjacent tissues of 63 cases of patients w...

Sequence length 30528; CDS 3768. 27 exons; total exon length 4477, max. exon length 969, min exon length 48. Number of SNPs 11. Polymorphisms: allelic variations at amino acid positions 654 and 655 of isoform (a) (positions 624 and 625 of isoform (b)) have been reported, with the most common Allele B1 (Ile654/Ile-655); allele B2 (Ile-654/Val-655); allele B3 (Val-654/Val-655). This nucleotide po...

Morphological changes of S. mutans NCTC 10449S associated with growth in modified Jordan medium and FMC medium (Terleckyj et al., Infect. Immun. 11:649-655, 1975) were studied by scanning electron microscopy. The cells were bacillary in Jordan medium, but coccoid and of unequal size in FMC. Transfer of the cells from Jordan medium to FMC and vice versa reversed their shapes, as did salt exchang...

1 INRIA Grenoble, 655 avenue de l’Europe, 38330 Montbonnot Saint Martin, France 2 Université de Grenoble , LIG, 51 avenue Jean Kuntzmann, 38330 Montbonnot Saint Martin, France 3 4D View Solutions, 655 avenue de l’Europe, 38330 Montbonnot Saint Martin, France 4 INRIA Lille-Nord Europe, LIFL, Parc Scientifique de la Haute Borne, 59650 Villeneuve d’Ascq, France 5 Université Bordeaux, LaBRI, INRIA ...