Stabilization of protein-protein interactions by small molecules is a concept with few examples reported to date. Herein we describe the identification and X-ray co-crystal structure determination of IBE-667, an ICAM-1 binding enhancer for LFA-1. IBE-667 was designed based on the SAR information obtained from an on-bead screen of tagged one-bead one-compound combinatorial libraries by confocal ...

A combination of radiotracer and pore-water concentration measurements provide evidence for the occurrence of acetogenesis from CO2 in anoxic marine sediments that are ordinarily dominated by sulfate reduction and methanogenesis. In a month-long incubation experiment using sediments from Cape Lookout Bight, North Carolina, we measured H2 and acetate concentrations and monitored the incorporatio...

*corresponding author Department of Pathology Beth Israel Deaconess Medical Center 330 Brookline Ave – YA309 Boston MA 02215 617-667-3648 (phone) 617-667-4533 (fax) [email protected] Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Clin. Microbiol. doi:10.1128/JCM.02595-10 JCM Accepts, published online ahead of print on ...

Using FrCas(E) retrovirus-infected newborn mice as a model system, we have shown recently that a long-lasting antiviral immune response essential for healthy survival emerges after a short treatment with a neutralizing (667) IgG2a isotype monoclonal antibody (MAb). This suggested that the mobilization of adaptive immunity by administered MAbs is key for the success in the long term for the MAb-...

107 ISSN 1758-2008 10.2217/NPY.12.75 © 2013 Future Medicine Ltd Neuropsychiatry (2013) 3(1), 107–115 Harvard Longwood Psychiatry Residency Training Program, Boston, MA, USA Beth Israel Deaconess Medical Center, 330 Brookline Avenue – Rabb 2, Boston, MA 02115, USA Sentara Neurology Specialists, Norfolk, VA, USA *Author for correspondence: Tel.: +1 617 667 2300 ext. 14233; Fax: +1 617 667 5575; a...

Effect of drought on apoplastic protein content, protein pattern, enzymic activiteis and minieral concentration of Vicia faba cv Giza 40 (relatively drought-tolerant) and Vicia faba cv Giza 667 (relatively drought-sensitive) was studied. While drought decreased Na, K, Ca concentration in leaf apoplast of Giza 40, it increased Na and Ca concentraion in case of Giza 667. Giza 40 has K:Na ratio hi...

Dr. Weaver is Associate Director, Center for Educational Policy and Research; Ms. Whittaker is Managing Editor; Dr. Valachovic is Executive Director; and Ms. Broom is Associate Executive Director and General Counsel, all at the American Dental Education Association. Direct correspondence to Angela Broom, American Dental Education Association, 1625 Massachusetts Ave., NW, Washington, DC 20036; 2...

Irosustat is a novel steroid sulfatase inhibitor for hormone-dependent cancer therapy. Its structure is a tricyclic coumarin-based sulfamate that undergoes desulfamoylation in aqueous solution, yielding the sulfamoyl-free derivative, 667-coumarin. The aim of the present work was to study the in vitro metabolism of irosustat, including its metabolic profile in liver microsomes and hepatocytes, t...