Prabha Balaram1,*, Smriti M Krishna1, Susan James2, Vino. T. Cheriyan1, Sreelekha Therakathinal Thankappan1, Aleyamma Mathew3 Division of Cancer Research, Regional Cancer Centre, Medical College. P.O, Trivandrum 695 011, Kerala, India. Department of ENT, Medical College, Trivandrum 695-011, Kerala, India Department of Statistics, Regional Cancer Centre, Trivandrum, Kerala, India _______________...

Large conductance voltage- and Ca(2+)-activated potassium channels (BK channels) are important feedback regulators in excitable cells and are potently regulated by protein kinases. The present study reveals a dual role of protein kinase C (PKC) on BK channel regulation. Phosphorylation of S(695) by PKC, located between the two regulators of K(+) conductance (RCK1/2) domains, inhibits BK channel...

Let us consider two closed homeomorphic manifolds M;N of class C 1 and two functions j : M ! R, c : N ! R of class C . The natural pseudodistance d between the pairs ðM; jÞ; ðN;cÞ is defined as the infimum of Yð f Þ 1⁄4 def maxP AMjjðPÞ cð f ðPÞÞj, as f varies in the set of all homeomorphisms from M onto N. In this paper we prove that a suitable multiple of d by a positive integer k coincides w...

The prothrombinase complex catalyzes the activation of prothrombin to alpha-thrombin. We have repetitively shown that amino acid region (695)DYDY(698) from the COOH terminus of the heavy chain of factor Va regulates the rate of cleavage of prothrombin at Arg(271) by prothrombinase. We have also recently demonstrated that amino acid region (334)DY(335) is required for the optimal activity of pro...

clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): April 18, 2013 www.sciencemag.org (this information is current as of The following resources related to this article are avail...

The myosin phosphatase (MP) composed of the catalytic subunit of type 1 protein phosphatase and myosin phosphatase target subunit isoform 1 (MYPT1) was identified as the major serine/threonine phosphatase component in the platelet-cytoskeleton fraction. MYPT1 was phosphorylated by cytoskeletal kinase(s), but the identity of the kinase(s) and the effect of phosphorylation were not established. I...

www.sciencemag.org (this information is current as of August 11, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/283/5402/695 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/283/5402/695#otherarticles , ...

Physics 695, Fall 2015. September 9, 2015. Version December 10, 2015