Background: Women worldwide are concerned about breast cancer, resulting in high mortality and morbidity. Objectives: In this research, to investigate the function of Taxol, Vinblastine, Vincristine on MCF-7 cell line, different concentration levels (10, 20, 40, 80, 160, 320 µmol/mL) drugs were examined. Taxolwas also used combination with Vinblastine Vincristine. Methods: The examined compound...

cancer cell-stromal cell interaction plays a crucial role in the growth and invasion of tumor cells of various organs. it has been recently suggested that adipocytes and preadipocytes, two specific types of stromal cells, affect the biological behavior of variety of breast cancer cell lines. in spite of few investigations, there is a controversy in the literatures about the effects of adipocyte...

objective: verotoxin is a member of shiga toxin family. this family contains ab protein toxins with an enzymatic (a) and a binding (b) compartment. cells that have receptor (gb3) are sensitive to cytotoxic effects of toxin. it has been shown that various tumor cells have gb3 receptor and are selectively sensitive to apoptotic effect of verotoxin. studies on tumor cell lines and laboratory anima...

objective: today, special attention is paid to the use of zirconium dioxide nanoparticle (nano-zro2), a neutral bioceramic metal, particularly for drug and gene delivery in medicine. however, there are some reports implying that use of nano-zro2 is associated with cytotoxic effects like inhibiting the cell proliferation, dna damage and apoptosis. in the present study, we examined whether nano-z...

background: the monoclonal antibody, c595, against breast cancer cell line was conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (gd-cdtpaa) to produce gd-dtpa-c595 and used as specific breast cancer cell line (mcf-7) contrast agents in magnetic resonance imaging (mri).  methods: after incubation of breast cancer cell line (mcf-7), with different contrast agents (g...

background: ß-carbolines, harmaline and harmine, are the major alkaloids presenting in the seeds of the peganum harmala l. these alkaloids are known as herbal active principals with potential use in pharmaceutical and medicine. objectives: to assess the growth inhibitory effect of phyto-alkaloids, harmaline and harmine, on cancer cell lines. methods: the p. harmala l.’s alkaloids were extracted...

background: nigella sativa has been a nutritional flavoring factor and natural treatment for many ailments for so many years in medical science. earlier studies have been reported that thymoquinone (tq), an active compound of its seed, contains anticancer properties. previous studies have shown that tq induces apoptosis in breast cancer cells but it is unclear the role of p53 in the apoptotic p...

objective: a number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. it has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (no) production. these data suggest that the cytotoxic effect of saffron extra...

background: erythropoietin (epo) is a glycoprotein hormone function to regulate the production of red blood cells. deficiency of epo is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. availability of recombinant epo has eliminated the need for blood transfusion and now it is extensively used for the treatment of anemia. glycosylation of e...