The cerebellum is critical for motor coordination and cognitive function and is the target of transformation in medulloblastoma, the most common malignant brain tumor in children. Although the development of granule cells, the most abundant neurons in the cerebellum, has been studied in detail, the origins of other cerebellar neurons and glia remain poorly understood. Here we show that the muri...

KATHERINE P. O’NEILL*, DANIEL D. RICHTER and ERIC S. KASISCHKE USDA Agricultural Research Service, Appalachian Farming Systems Research Center, 1224 Airport Rd, Beaver WV 25813, USA; Nicholas School of the Environment and Earth Sciences, Duke University, Durham NC 27708-0328, USA; Department of Geography, University of Maryland, College Park MD 20742-8225, USA; *Author for correspondence (e-mai...

El podcasting se debate entre posibilitar las culturas participativas gracias a la expresión personal y cultural de podcasters independientes o ser una industria promovida desde los medios periodísticos “plataformización” del mercado comunicación. caso contexto sociocultural Puerto Rico también enfrenta esta cuestión es interés identificar oferta estable regular pódcast nativos realizada por se...

The pharmacological profile of a new alpha-1 adrenoceptor antagonist, alpha-ethyl-3,4,5-trimethoxy-alpha-(3-((2-(2-methoxyphenoxy)ethyl)amino) propyl) benzene-acetonitrile fumarate (HV-723), was studied in vitro. In dog mesenteric arteries, HV-723, prazosin and yohimbine competitively inhibited noradrenaline-induced contraction: the pA2 value of HV-723 (9.37) was apparently larger than that of ...

Carbon monoxide (CO) is an important building block in industrial organic chemistry. Organic substrates containing a carbon-carbon unsaturation may undergo an addition of CO, normally resulting in the formation of a new carbon-carbon sequence, where one carbon atom is provided by carbon monoxide, the other ones originating from the unsaturated substrate, e.g. an olefin or an acetylenic derivati...

The current article presents the process of situated modeling in the drawing workshop for bobbin lace developed and implemented in the Núcleo de Produção Artesanal Rendeiras da Vila, in Ponta Negra, Natal-Brasil. The workshop aimed to rescue the domain over the product in the production of bobbin lace through capacitation of both experienced and novice craftswomen. The modeling of the drawing w...