The brain microenvironment promotes metastasis through mechanisms that remain elusive. Co-culture of lung cancer cells with astrocytes - the most abundant cell type within the metastatic brain niche - lead to downregulation of miRNA-768-3p which drives K-ras expression and key signaling pathways, enhances cell viability and promotes chemotherapeutic resistance. Vector-based forced expression of...

This paper reports on the factorization of the 768-bit number RSA-768 by the number field sieve factoring method and discusses some implications for RSA.

Over the past two centuries human life expectancy has increased by nearly 50 years. Genetic factors account for about one-third of the variation in life expectancy so that most of the interindividual variation in lifespan is explained by stochastic and environmental factors, including diet. In some model organisms, dietary (energy) restriction is a potent, and highly reproducible, means of incr...

1. Abstract 2. Introduction 2.1. Clinical need for vascular tissue engineering 2.1.1.Cardiovascular disease 2.1.2. End stage renal disease 3.1.3. Need for a new graft material 2.2. Current issues in vascular tissue engineering 2.2.1. Cell source 2.2.2. Scaffolds 2.2.3. Mechanical stimulation 2.2.4. Biochemical stimulation 3. Cellular constituents for vascular tissue engineering 3.1. Terminally ...

Common bean anthracnose caused by Colletotrichum lindemuthianum is one of the major biotic constraints to production French beans (Phaseolus vulgaris L.) in Kenya. This study aimed at screening genotypes relation their response common order identify potential sources germplasm for breeding. The were tested three sites (Kakamega, Mwea and Kutus) where results revealed a significant genotype envi...

PRIMA-1met (APR-246) is a methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis). PRIMA-1met has been reported to restore both the wild type (wt) structure and function of mutant p53. Here, we show that PRIMA-1met is highly effective at limiting the growth of CRC cells regardless of p53 status. However, PRIMA-1met induces robust apoptosis o...

Based on discrete event-triggered communication scheme (DETCS), this paper is concerned with the satisfactory H ! / H 2 event-triggered fault-tolerant control problem for networked control system (NCS) with α -safety degree and actuator saturation constraint from the perspective of improving satisfaction of fault-tolerant control and saving network resource. Firstly, the closed-loop NCS model w...

ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, tolerability, and pharmacokinetics of ST-246 administered as a single daily oral dose of 250, 400,...