BACKGROUND There is little information on lung function and respiratory diseases in people with psychosis. AIMS To compare the respiratory health of people with psychosis with that of the general population. METHOD In a nationally representative sample of 8028 adult Finns, lung function was measured by spirometry. Information on respiratory diseases and symptoms was collected. Smoking was q...

Survivin is an inhibitor of apoptosis proteins and plays a crucial role in the development of cancer. Numerous studies have evaluated the association between survivin 31G>C polymorphism (rs9904341) and the risk of cancer, but the results of these studies remain inconclusive. Therefore, we conducted this updated meta-analysis to further examine this association. A total of 33 studies of 8028 cas...

M e t h o d s Design: Randomized controlled trial (Breast International Group [BIG] 1-98 study). Allocation: Concealed.* Blinding: Blinded {patients, clinicians, outcome assessors, data analysts, and data safety and monitoring committee}†.* Follow-up period: Median 26 months. Setting: Several hundred centers worldwide. Patients: 8028 postmenopausal women 38 to 90 years of age (median age 61 y) ...

BACKGROUND Obesity is a major public health problem worldwide. Metabolic syndrome is a risk factor to the cardiovascular diseases. It has been reported that disruptions of the circadian clockwork are associated with and may predispose to metabolic syndrome. METHODOLOGY AND PRINCIPAL FINDINGS 8028 individuals attended a nationwide health examination survey in Finland. Data were collected with ...

BACKGROUND Available information about the association between education and physical fitness (PF) is scarce. The purpose of this study was to examine educational differences in PF in the working age population using different methods to assess PF. METHODS The Health 2000 Survey was carried out for adults aged ≥ 30 years (n = 8028) in Finland. For this study, 30-54-year-old men and women with...

BACKGROUND & OBJECTIVES Literature reports several studies on ABO groups and malaria but a study with an adequate sample size and controls is not available. ABO groups are genetically controlled, hence, large sample size and comparison with population frequency is essential. To determine whether malaria infection with variable severity has correlation with ABO groups. STUDY DESIGN & METHODS B...

OBJECTIVE The aim of this study was to determine the effect of exposure to different antithyroid drugs during pregnancy on the incidence of neonatal congenital malformations. METHODS A meta-analysis was performed to compare the incidence of neonatal congenital malformations after exposure to different antithyroid drugs during pregnancy. Twelve studies that met the inclusion criteria were incl...

OBJECTIVE The aim of the study was to investigate the association between serum lipids and periodontal infection and the role of serum lipids in the association between body weight and periodontal infection. MATERIAL AND METHODS The Health 2000 Health Examination Survey, which included 8028 subjects aged 30 or older living in continental Finland. This study was based on a subpopulation of den...

The cDNA of human medium chain acyl-CoA dehydrogenase (MCADH) was modified by in vitro mutagenesis, and the sequence encoding the mature form of MCADH was introduced into an inducible expression plasmid. We observed synthesis of the protein in Escherichia coli cells transformed with this plasmid with measurable MCADH enzyme activity in cell extracts. Glutamic acid 376, which has been proposed b...