ing Security Specifications in Building Survivable Systems J. Jenny Li and Mark Segal Telcordia Technologies (formerly Bellcore) 445 South Street, Morristown NJ 07960-6438 USA Email: [email protected]; Phone: (973)829-4753; Fax: (973)829-5981

Transmembrane drug export mediated by the ATP-binding cassette (ABC) transporter P-glycoprotein contributes to clinical resistance to antineoplastics. In this study, we identified the substituted quinoline HG-829 as a novel, noncompetitive, and potent P-glycoprotein inhibitor that overcomes in vitro and in vivo drug resistance. We found that nontoxic concentrations of HG-829 restored sensitivit...

UNLABELLED With the recent discovery of recurrent mutations in the TERT promoter in melanoma, identification of other somatic causal promoter mutations is of considerable interest. Yet, the impact of sequence variation on the regulatory potential of gene promoters has not been systematically evaluated. This study assesses the impact of promoter mutations on promoter activity in the whole-genome...

Over-segmentation, or super-pixel generation, is a common preliminary stage for many computer vision applications. New acquisition technologies enable the capturing of 3D point clouds that contain color and geometrical information. This 3D information introduces a new conceptual change that can be utilized to improve the results of over-segmentation, which uses mainly color information, and to ...

www.sciencemag.org (this information is current as of May 27, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/301/5634/829 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/301/5634/829#otherarticles , 14 ...

Doğu Roma İmparatorluğu olarak da isimlendirilen 330-1453 yılları arasında geniş topraklarda hüküm süren Bizans İmparatorluğu, araştırmacıların sıklıkla ilgisini çekmiştir. 20. yüzyılın sonuna kadar bu konuda yapılan araştırmalar, siyasî, idarî ve askerî alanlarda olmuştur. İmparatorluğu’nun saray kültürü sosyal hayatını esas alan çalışmalar eksiklik teşkil etmiştir. 1994 yılında literatürdeki ...

0377-2217/$ see front matter 2013 Elsevier B.V. All rights reserved. http://dx.doi.org/10.1016/j.ejor.2013.03.012 ⇑ Corresponding author. Tel.: +1 814 865 3841; fax: +1 814 863 4745. E-mail addresses: [email protected] (J.A. Ventura), [email protected] (V.A. Valdebenito), [email protected] (B. Golany). 1 Tel.: +1 814 865 3841; fax: +1 814 863 4745. 2 Tel.: +972 4 829 4512; fax: +972 4 829 5688. ...

Running Title: HG-829, A Novel Pgp Inhibitor