http://bmj.com/cgi/content/full/333/7576/983 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/333/7576/983#otherarticles 6 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/333/7576/983#BIBL This article cites 5 articles, 3 of which can be accessed free at: Rapid responses http://bmj.com/cgi/elet...

A pharmacokinetic model was constructed to explain the difference in brainand cerebrospinal fluid (CSF)-to-plasma and brainto-CSF unbound drug concentration ratios (Kp,uu,brain, Kp,uu,CSF, and Kp,uu,CSF/brain, respectively) of drugs under steady-state conditions in rats. The passive permeability across the blood-brain barrier (BBB), PS1, was predicted by two methods using log(D/molecular weight...

We have identified a novel temperature-sensitive mutant of fission yeast alpha-tubulin Atb2 (atb2-983) that contains a single amino acid substitution (V260I). Atb2-983 is incorporated into the microtubules, and their overall structures are not altered noticeably, but microtubule dynamics is compromised during interphase. atb2-983 displays a high rate of chromosome missegregation and is syntheti...

Abstract Background Activins are members of the transforming growth factor-? superfamily implicated in pathogenesis several immunoinflammatory disorders. Based on our previous studies demonstrating that overexpression activin-A murine lung causes pathology sharing key features coronavirus disease 2019 (COVID-19), we hypothesized activins and their natural inhibitor follistatin might be particul...

Address correspondence to: Dr. Victor J. Dzau Mandel Center for Hypertension Research Division of Cardiovascular Medicine Department of Medicine Duke University Medical Center, Box 3701 GSRBII, 210 Research Drive Durham, NC 27710 Tel: 919-684-2255 Fax: 919-684-4801 [email protected] Dr. Sophie Dal-Pra Mandel Center for Hypertension Research Division of Cardiovascular Medicine Department of M...

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Lifelong learning is becoming a necessity in the new Information Society where everyone, particularly small and medium sized enterprises (SMEs), must keep up with new technologies. Education and training are of the most importance in this updating. An interdisciplinary and inter-university work group called "Canalejas" (Spain) has developed a multimedia educational CD-ROM, "Basic Course on Tele...

The alpha4 laminin subunit is a component of the basement membrane of blood vessels where it codistributes with the integrins alphavbeta3, alpha3beta1, and alpha6beta1. An antibody against the G domain (residues 919-1207; G(919-1207)) of the alpha4 laminin subunit inhibits angiogenesis in a mouse-human chimeric model, indicating the functional importance of this domain. Additional support for t...

Objective: To assess convergence among three different measures of indiscriminate behavior and to assess the relationship of indiscriminate behavior to having an attachment figure and to aggressive behavior among young children living in a Romanian institution. Method: Caregivers in the institution were interviewed with semistructured interviews regarding the behavior of 61 children with specia...

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