Introduction: Aspergillus fumigatus is the leading cause of invasive aspergillosis in immunocompromised patients with a high rate of mortality. Despite introduction of several classes of antifungal drugs, the limitations of current therapies have prompted an intense research toward the discovery of new antifungal compounds. In a recent study, several potential drug targets were identified based...

Background and Purpose: Aspergillosis is one of the most common opportunistic fungal infections in immunocompromised and neutropenic patients. Aspergillus fumigatus (A. fumigatus) is the most common causative agent of this infection. Due to variable CO2 concentrations that pathogens are exposed to during the infection process and to understand the role of CO2, we examined the effects of various...

significant dropping of infectious disease is owned greatly to antibiotic development industry. due to prevalence of drug resistance organisms alongside with other problems, scientists are focusing on medicinal plants. medicinal plants and their antimicrobial components are attractive alternatives for antibiotics. in the present project, the antimicrobial effects of methanolic extract and fract...

Aspergillus fumigatus is the most prevalent airborne fungal pathogen that induces serious infections in immunocompromised patients. Phospholipases are key enzymes in pathogenic fungi that cleave host phospholipids, resulting in membrane destabilization and host cell penetration. However, knowledge of the impact of phospholipases on A. fumigatus virulence is rather limited. In this study, disrup...

While the epidemiology and clinical differences of various Candida spp. has been relatively well-identified, data regarding invasive aspergillosis (IA) caused by different Aspergillus spp. are insufficient.We aimed to determine the epidemiology of culture-positive invasive pulmonary aspergillosis (IPA) and to compare the characteristics and outcomes of Aspergillus fumigatus IPA with those of no...

Growth inhibition of Aspergillus fumigatus,Aspergillus flavus and Fusarum solani exposed to the essential oils including Thyme, Agastache and Satureja were studied. Disc Diffusion Method was used to evaluate the fungal growth inhibitory effects of the essential oils. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of the oils were determined and compared with ...

invasive aspergillosis (1 is a life-threatening condition in immunocompromised patients. an early diagnosis is of great importance because early treatment may resolve this potentially fatal infection. recently, the polymerase chain reaction (pcr) has been used successfully in detecting specific dna of several pathogen. in this study, nested pcr was used to detect dna specific for a!.pergiflus s...

a 46- year–old man with pulmonary tuberculosis which had treated with ant tuberculosis drugs was referred to medical mycology laboratory, school of public health and institute of public health research for coughing and bloody sputum. chest x-ray revealed a cavern with a moveable mass in right apical lobe. direct examination of sputum showed wide septated dichotomous hyphae and aspergillus fumig...

background vancomycin-resistant enterococci (vre) are the most common nosocomial pathogen worldwide. colonization with vre can lead to serious infection, some of which e.g. vre sepsis can be fatal. because vre are dangerous important pathogens, we aimed to determine the prevalence of vre among patients admitted in infectious, icu and surgery wards in a referral teaching hospital in isfahan, ira...

Aspergillus fumigatus is a fungus that causes opportunistic infections in immunocompromised patients, with high morbidity and mortality. In its turn, A. fumigatus can become infected with mycoviruses. Most mycoviruses have a dsRNA genome and can cause fungal hypovirulence. For that reason, mycoviruses could theoretically be used as therapeutic tools to combat fungal infections. We determined if...