BACKGROUND Schizophrenia is a complex genetic disorder with no clear pattern of inheritance. Epigenetic modification of genes may thus play a role in its transmission. METHODS In our study, 439 families with at least two ill siblings with schizophrenia (208 with unilineal transmission) were examined for evidence of a parent-of-origin effect (e.g., evidence of parental imprinting on the famili...

What's the neurocognitive deficit as an endophenotype to familial schizophrenia? Here, we investigate the neurocognitive endophenotype in first-episode patients with familial schizophrenia (FS) and sporadic schizophrenia (SS), and their parents. 98 FS patients and their 105 parents; 190 SS patients and their 207 parents; 195 controls matched with patients, and 190 controls matched with the pati...

schizophrenia is a chronic psychotic disorder with unknown etiology that causes cognitive impairment, affecting thinking, behavior, social function, sleep and dream content. this study considered the dream content of patients with schizophrenia, siblings of patients with schizophrenia, patients with psychiatric diagnoses other than schizophrenia, and a group of healthy controls. the aim of this...

OBJECTIVE To develop a reliable and valid parent-report screening instrument for mania, based on DSM-IVsymptoms. METHOD A 21-item Child Mania Rating Scale-Parent version (CMRS-P) was completed by parents of 150 children (42.3% female) ages 10.3 +/- 2.9 years (healthy controls = 50; bipolar disorder = 50; attention-deficit/hyperactivity disorder [ADHD] = 50). The Washington University Schedule...

Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified proband. Peripheral blood mononuclear cells obtained all three individuals reprogrammed using Sendai virus particles carrying Yamanaka transgenes. These iPSC...

Ebeveynde ruhsal hastalık tanısı bulunması hem çocuk de ebeveyn için oldukça sıkıntılı yaşam deneyimlerine sebep olabilmektedir. Şizofreni ve/veya bipolar bozukluk ile takip edilen anne/baba çocuklarının bireysel ve toplumsal birçok zorlukla mücadele ettikleri bilinmektedir. Her çocuğun deneyimi eşsiz özel olsa da aralarında dramatik benzerlikler olduğu görülmektedir. Çocuklar korku, utanma, üz...

Univariate prediction models of schizophrenia may be adequate for hypothesis testing but are narrowly focused and limited in predictive efficacy. Therefore, we used a multivariate design to maximize the prediction of schizophrenia from premorbid measures and to evaluate the relative importance of various predictors. Two hundred twelve Danish subjects with at least one parent diagnosed in the sc...

objective: the relationship between obsessive compulsive disorder and schizophrenia has been a matter of dispute for ages. this study aimed to investigate the differences between schizophrenia with obsessive compulsive symptoms (ocs) and schizophrenia without ocs in affecting positive and negative symptoms of schizophrenia.  methods: study participants comprised 30 patients with schizophrenia w...

background : schizophrenia is a serious, chronic, and often debilitating neuropsychiatric disor­der. its causes are still poorly understood. besides genetic and non-genetic (environmental) fac­tors are thought to be important as the cause of the structural and functional deficits that character­ize schizophrenia. this study aimed to compare toxoplasma gondii infection between schizo­phrenia pat...