BACKGROUND Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder involving aberrant proliferation of multiple tissues of neural crest origin. Retinal vascular alterations in NF1 have rarely been reported in the literature and their nature is not clear. This study describes distinctive retinal microvascular alterations and their relationship to choroidal nodules in patients with neuro...

PURPOSE To determine the efficacy of rAAV.sFlt-1-mediated gene therapy in a transgenic mouse model of retinal neovascularization (trVEGF029) and to assess whether rAAV.sFlt-1 administration generated any deleterious, long-lasting immune response that could affect efficacy. METHODS trVEGF029 mice were injected subretinally with rAAV.sFlt-1 or phosphate-buffered saline. Fluorescein angiography ...

In this paper we consider the problem of blood vessel segmentation in retinal images. After enhancing the retinal image we use green channel of images for segmentation as it provides better discrimination between vessels and background. We consider the negative of retinal green channel image as a topographical surface and extract ridge points on this surface. The points with this property are l...

Purpose Congenital retinal macrovessels (CRM) represent rare aberrant vasculature of the retinal vessels that can supply or drain the macula. In this report, the optical coherence tomography angiography features of a congenital retinal macrovessel are discussed. Methods The history and examination findings are presented alongside swept-source OCT angiography with corresponding B scan and en f...

Diabetic retinopathy lesion detection such as exudate in fundus image of retina can lead to early diagnosis of the disease. Retinal image includes dark areas such as main blood vessels and retinal tissue and also bright areas such as optic disk, optical fibers and lesions e.g. exudate. In this paper, a multistage algorithm for the detection of exudate in foreground is proposed. The algorithm se...

Phototoxic retinopathy in rats is characterized by a progressive loss of the outer retinal layers. During the neural degenerative phases, a sequence of vascular change occurs. Whole mounts of ink-injected retinal vessels and flat mounts of trypsin-digested retinal vessels show areas of capillary nonperfusion and acellularity and enlargement of retinal capillaries in the deep bed. When the photo...

Computerized segmentation of retinal vessels can help doctors discover diabetic retinopathy, Retinal Tear and Detachment. Because the anatomy is complicated changing, automated vessel still a difficult task. The Expectation-Maximization approach for vascular proposed in this paper, which uses matched filter (MF) that combines Mask based Blood Vessels Extraction with global image threshold to ex...

uncontrolled hypertension is well- known to give rise to systemic complications involving multiple central organs. artherosclerosis leads to damage of the retinal vessels wall, contributing to venous stasis, thrombosis and finally, occlusion. retinal vein occlusions compromise vision through development of ischaemic maculopathy, macular oedema, and rubeotic glaucoma. laser photocoagulation rema...