UNLABELLED Paraneoplastic acanthosis nigricans is connected with malignancies in adults in almost 100% of cases. The typical skin changes include: thickening and hyperpigmentation in typical localization with mucocutaneous involvement. PURPOSE The authors report a case of a malignant type of acanthosis nigricans in 42-year-old female patient with hepatocellular carcinoma. CASE REPORT First ...

BACKGROUND Acanthosis nigricans is characterized by hyperpigmentation and hyperkeratosis of the skin or mucous membranes. Its malignant form is associated with internal neoplasms, especially gastric adenocarcinoma (55-61%). Coexistence with prostate cancer is uncommon. In the paraneoplastic type of this dermatosis, the skin and mucous lesions are characteristically of more sudden onset and more...

The combination of Crouzon syndrome with acanthosis nigricans is unusual. The incidence of this combination is still uncertain, and there are only 30 cases reported in the medical literature. Crouzon syndrome is caused by mutation of the gene FGFR3 (fibroblast growth factor receptor 3). In this gene, other mutations can cause a kind of nanism that is lethal during the first weeks of life. Recen...

Confluent and reticulated papillomatosis is a rarely reported dermatosis of unknown origin. It is similar to nummular and confluent papillomatosis; punctate, pigmented verrucose papillomatosis; acanthosis nigricans; pseudoacanthosis nigricans; benign acanthosis nigricans; pseudoatrophoderma colli; tinea versicolor; Darier's disease; epidermodysplasia verruciformis; and verruca plana. Treatment ...

florid cutaneous papillomatosis (fcp), is a rare cutaneous marker of internal malignancy. the underlying cancer is usually intra-abdominal (most often gastric in origin), and evolves parallel to the fcp. there is a common association between fcp and the other two eruptive paraneoplastic syndromes, i.e.malignant acanthosis nigricans and the sign of leser-trelat. it seems possible that these synd...