The binding determinants of the human acyl-CoA binding domain-containing protein (ACBD) 6 and its function in lipid renewal of membranes were investigated. ACBD6 binds acyl-CoAs of a chain length of 6 to 20 carbons. The stoichiometry of the association could not be fitted to a 1-to-1 model. Saturation of ACBD6 by C16:0-CoA required higher concentration than less abundant acyl-CoAs. In contrast ...

Cutaneous mast cell responses to physical (thermal, mechanical, or osmotic) stimuli underlie the pathology of physical urticarias. In vitro experiments suggest that mast cells respond directly to these stimuli, implying that a signaling mechanism couples functional responses to physical inputs in mast cells. We asked whether transient receptor potential (vanilloid) (TRPV) cation channels were p...

11 12 The activity of phosphatidylinositol 4-kinase class III beta (PI4KIIIβ) has been shown to 13 be required for the replication of multiple picornaviruses, however it is unclear whether a 14 physical association between PI4KIIIβ and the viral replication machinery exists and if it 15 does, whether association is necessary. We examined the ability of the 3A protein from 16 18 different picorn...

It has been a well known fact for over 60 years that the genome undergoes rearrangements, or what seem to be a general scrambling of the order of the genome. In the salivary glands of Drosophila, a phenomenon of chromosomes doubling in thickness during mitosis has been noticed. This appears to be two homologs (identical copies of a chromosome segment created during cell division) that have glue...

The level N and squarefree character q of a positive definite ternary quadratic form are defined so that its associated modular form has level N and character Xg ■ We define ä collection of correspondences between classes of quadratic forms having the same level and different discriminants. This makes practical a method for finding representatives of all classes of ternary forms having a given ...

A graph is a triangulation if it is planar and every face is a triangle. A triangulation is rooted if the external triangular face is labelled. Two rooted triangulations with the same external face labels are isomorphic if their internal vertices can be labelled so that both triangulations have identical edge lists. In this article, we show that in the set of rooted triangulations on n points w...

Recent research on the impact of new communication and information technologies stress the transformation that new forms of mediated interactions are having on the ways that teenagers, especially, participate and make sense of different aspects of their lives, including education. The Virtual Math Teams (VMT) project is an NSF-funded research program that investigates the innovative use of onli...