Cryothermia, a new technique for definitive treatment of the pre-excitation syndrome, is described in two patients. The first patient presented with a normal P-R interval with a delta wave and reciprocating tachycardia. Preoperative electrophysiologic study suggested a free-wall atrioventricular connection on the left posterior atrioventricular (A-V) groove. At surgery, epicardial mapping confi...

Clathrin-mediated endocytosis is a major pathway for the internalization of macromolecules into the cytoplasm of eukaryotic cells. The principle coat components, clathrin and the AP-2 adaptor complex, assemble a polyhedral lattice at plasma membrane bud sites with the aid of several endocytic accessory proteins. Here, we show that huntingtin-interacting protein 1 (HIP1), a binding partner of hu...

BACKGROUND Pseudo-Mahaim (AP-M) fibers are a rare variant of atrioventricular (AV) accessory pathways. Atriofascicular and atrioventricular accessory connections are characterized by slow conduction and decremental properties. Dual physiological AV node pathways, slow and fast, are observed in a large number of patients with AP-M. Therefore, there is substrate for AV nodal reentrant tachycardia...

The differentiation of the retrograde conduction pathway is essential for the diagnosis of paroxysmal supra ventricular tachycardia (PSVT). An eccentric retrograde atrial activation sequence during the tachycardia could give rise to a diagnosis of accessory pathway (AP) conduction. However, in the case of PSVT, which exhibits a concentric retrograde atrial activation sequence, it is confusing t...

A 10-year-old boy with a supraventricular tachycardia was referred for catheter ablation. An electrophysiologic study revealed a left lateral concealed accessory pathway (AP). A few radiofrequency (RF) applications targeting the AP resulted in an inadvertent intra-atrial conduction block at the mitral isthmus without any damage to the AP. Adenosine was then administered during left ventricular ...

A 42-year-old man was referred to our hospital for an electrophysiologic study because of recurrent episodes of palpitation. On coronary angiogram, an anomalous atresia of the coronary sinus (CS) ostium was discovered. The ablation catheter was inserted from the right femoral artery to the accessory pathway (AP) of posterior paraseptal area. The earliest retrograde atrial activation was recorde...

Reciprocating tachycardia in a patient with a leftsided atrioventricular accessory pathway (AP) (Kent bundle, type A) capable only of ventriculo-atrial (V-A) transmission is described. The V-A AP is established as an essential link of the tachycardia circuit, as evidenced by: 1) retrograde atrial activation of the left atrium (LA) 60 msec or more before the low and high right atrium during reci...

We report observations in a 7-year-old girl with right ventricular pre-excitation due to an accessory atrioventricular pathway (AP), and depressed cardiac function. Echocardiographic findings consisted of left ventricular (LV) dilatation with asynchronous ventricular wall motion and diminished LV ejection fraction. Electrophysiological study revealed a para-Hisian AP. She underwent successful A...

In the case presented by Drs. Tanaka-Esposito and Cantillon, a patient deemed to be at risk of developing unpredictable atrioventricular (AV) block based on electrophysiology findings and a catheter ablation procedure is chosen for the implantation of a leadless pacemaker that will provide permanent, prophylactic ventricular pacing. Briefly, this case involved a patient with a midseptal accesso...