Filariasis is a major health problem, affecting millions of people in tropical and subtropical regions of the world. Targeting the parasite specific enzyme is not only rational but essential for developing effective control measure against filariasis. In our earlier studies we have identified two isozymic forms of acetylcholinesterase (AchE) from bovine filarial parasites (Setaria cervi) differ...

donepezil, a member of the acetylcholinesterase inhibitor family, is approved for management of cognitive impairments as well as behavioral complications in patients with neurodegenerative alzheimer's disease. generally, donepezil is regarded as a safe medication in patients with alzheimer's disease although there have been reports of several minor adverse events including gastrointestinal dist...

Pisa syndrome is characterised by a tonic flexion of the trunk to one side and slight axial rotation in sagittal plane. Recently more cases have been reported Alzheimer's dementia patients treated with acetylcholinesterase inhibitor medication. Here authors present case an elderly lady donepezil highlight importance monitoring for side‐effects.

Rivastigmine transdermal patch is indicated for patients with Alzheimer's disease and dementia with Parkinson's disease. Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly involving the gastrointestinal tract, but few cardiovascular adverse effects have been reported. This report presents two cases of patients presenting with 3(rd) degree atrioventricula...

A series of 2-(4-phenylpiperazin-1-yl)pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized for the treatment Alzheimer’s disease (AD). Their bioactivities evaluated by Ellman’s method, results showed that most compounds displayed moderate inhibitory activities in vitro. Among them, compound 6g exhibited potent activity against AChE with ...

We previously reported that acetylcholinesterase plays a critical role in apoptosis and its expression is regulated by Ca(2+) mobilization. In the present study, we show that activated calpain, a cytosolic calcium-activated cysteine protease, and calcineurin, a calcium-dependent protein phosphatase, regulate acetylcholinesterase expression during A23187-induced apoptosis. The calpain inhibitor,...