The acid-base equilibrium of lorazepam was studied by means of potentiometry andmultiwavelengths spectrophotometry. The stoichiometric equilibrium constants were determinedat 25 °C and constant ionic strength 0.1 mol L-1 (NaCl). The acidity constants pK1=1.58±0.05and pK2=11.67±0.07 were found by potentiometry, and pK1=1.54±0.02 and pK2=11.61±0.03 bymulti-wavelengths spectrophotometry. Potentiom...

In previous papers (9, 14) we have discussed the changes that occur in the acid-base equilibrium of serum of normal women during pregnancy. In brief, these changes are reduction of the serum carbon dioxide content and serum proteins, accompanied by a comparable reduction of total base. These findings have been confirmed by Stander, Eastman, Harrison, and Cadden (21). The reduction of serum prot...

Two-dimensional infrared (2DIR) spectroscopy, which has been proven to be an excellent experimental method for studying thermally-driven chemical processes, was successfully used to investigate the acid dissociation equilibrium of HN3 in methanol (CH3OH) and dimethyl sulfoxide (DMSO) for the first time. Our 2DIR experimental results indicate that the acid-base equilibrium occurs on picosecond t...