Gaucher disease type 1, a non-neuronopathic lysosomal storage disease, is caused by mutations at the acid beta-glucosidase locus. Periodic infusions of macrophage-targeted acid beta-glucosidase reverse hepatosplenomegaly, hematologic, and bony findings in many patients. Two patients receiving enzyme therapy developed neutralizing antibodies to acid beta-glucosidase that were associated with a l...

HIV type 1 (HIV-1) can rapidly escape from neutralizing antibody responses. The genetic basis of this escape in vivo is poorly understood. We compared the pattern of evolution of the HIV-1 env gene between individuals with recent HIV infection whose virus exhibited either a low or a high rate of escape from neutralizing antibody responses. We demonstrate that the rate of viral escape at a pheno...

Abstract: Aim/Background: Imbalance in oxidant and antioxidant leads to stress. Increased consumption of exogenous antioxidants helps neutralizing the stress thus protects cells from The study focused on isolation nutraceutical compound, dodecanoic acid marine cyanobacteria Geitlerinema sp. TRV57. Materials Methods: Various solvents were used extract acid. ability neutralize was studied by vari...

Acid-base accounting (ABA) is intended to estimate the quantities of minerals potentially capable of generating and neutralizing acid using chemical procedures. The neutralization potential (NP) component of ABA is more complex than acid potential (AP) because the minerals quantified in the analytical result may or may not contribute significantly to acid neutralization under field conditions. ...

Precipitation is a well known phenomenon. If the pH of it is less than 5.6 precipitations are considered as acidic else it is alkaline. Basically soil is alkaline in nature. Recently man’s activities have increased emissions of oxides of nitrogen and sulphur results in increase in acidity of atmosphere. When these gases react with different elements in the atmosphere the acids are re-introduced...

Abstract Corrosion is considered one of the major problems that affect flow assurance during hydrocarbon production. This irreversible phenomenon has ability to cause serious material failure in oil and gas industry. Consequently, heavy capital operational costs are required prevent corrosion processes. Sweet raw production facilities an Algerian field manifests inside surface installations, wh...

Three peptides, D1 (amino acid residues 175-201), D2 (a.a. 434-467), and TM (a.a. 1128-1159), corresponding to the spike protein (S) of severe acute respiratory syndrome corona virus (SARS CoV) were synthesized and their immunological functions were investigated in three different animals models (mice, guinea pigs, and rabbits). The peptides mixture formulated either with Freund's adjuvant or s...

In the present study, the effectiveness of Mimosa pudica tannins (MPT) in neutralizing the lethality of Naja kaouthia venom was compared with commercially derived tannins. Preincubation of MPT with N. kaouthia venom maintained 100% survival of mice after 24 hours. The mouse group in which there was no preincubation, no protection against the effects of the venom was observed. M. pudica tannin w...