Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na(+) channels. However, it remains unknown whether it has any effects on K(+) currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular myocytes were investigated in this study. In H9c2 cells, ACO suppressed ultra...

Multiobjective evacuation routes optimization problem is defined to find out optimal evacuation routes for a group of evacuees under multiple evacuation objectives. For improving the evacuation efficiency, we abstracted the evacuation zone as a superposed potential field network (SPFN), and we presented SPFN-based ACO algorithm (SPFN-ACO) to solve this problem based on the proposed model. In Wu...

A hybrid population based Ant Colony Optimization (ACO) algorithm PFold-P-ACO for protein folding in the HP model is proposed in this paper. This is the first population based ACO algorithm in the bioinformatics. It is shown experimentally that the algorithms achieves on nearly all test sequences at least comparable results to other state of the art algorithms. Compared to the state of the art ...

A deterministic model for Ant Colony Optimization (ACO) algorithms is proposed and used to study the dynamics of ACO. The model is based on the average expected behaviour of ants. The behaviour of ACO algorithms and the model are analysed for certain types of permutation problems. It is shown numerically that decisions of the ants are inuenced in an intriguing way by the properties of the phero...

Kriging is an advanced geostatistical procedure that generates an estimated surface or 3D model from a scattered set of points. This method can be used for estimating resources using a grid of sampled boreholes. However, conventional ordinary kriging (OK) is unable to take locally varying anisotropy (LVA) into account. A numerical approach has been presented that generates an LVA field by calcu...

Ant colony optimization (ACO) has been successfully applied for combinatorial optimization problems, e.g., the travelling salesman problem (TSP), under stationary environments. In this paper, we consider the dynamic TSP (DTSP), where cities are replaced by new ones during the execution of the algorithm. Under such environments, traditional ACO algorithms face a serious challenge: once they conv...

INTRODUCTION Acute coronary occlusion (ACO) may also present as non-ST elevation myocardial infarction (NSTEMI) and thus veil the real threat. AIM Based on combined analysis of electrocardiography and echocardiography findings, we aimed to describe profile of NSTEMI patients at increased risk of ACO. MATERIAL AND METHODS It was a retrospective study that included patients referred for cardi...

BACKGROUND Patients with symptoms of both asthma and chronic obstructive pulmonary disease (COPD) may be classified with the term asthma-COPD overlap (ACO). ACO is of considerable interest as it is currently poorly characterised and has been associated with worse health outcomes and higher healthcare costs compared with COPD or asthma alone. Patients with ACO in Asia remain poorly described, an...

Using computing algorithms to generate personalized learning resources provide the needs and improve capabilities, preferences, academic performance of diverse learners is creating preferred environments. As more resources, strategies techniques are frequently added these e-learning systems, input data personalize path has been growing exponentially making swift responses learner’s requests dif...