NewDiagnosticMethod for LesionsWith TransepidermalMelanocyticMigration Transepidermal melanocytic migration (TEM) is a histological feature that is frequently observed in malignant melanoma but may also occur in nevi (eg, Spitz nevi, acral nevi). Pagetoid TEM is considered a key indicator of malignant disease.Werefer toanunusual case reportbyKerl et al1 in ayoung female patient. Elevenmelanomas...

BACKGROUND Because body weight-bearing produces a shift in the horny layer, acral melanocytic nevus on the body weight-bearing area of the sole showed a regular fibrillar pattern (FP) due to slanting of the melanin columns in the horny layer. On the other hand, acral lentiginous melanoma (ALM) on the body weight-bearing area of the sole tended to show irregular fibrillar pattern showing rather ...

The majority of melanocytic nevi on the soles may show 3 major dermoscopic patterns depending on the anatomical site on the sole [6] : the parallel furrow, the lattice-like, and the fibrillar patterns. Regular or irregular patterns should be identified in the fibrillar pattern. The regular fibrillar pattern is seen in acral volar melanocytic nevus, whereas the irregular fibrillar pattern is oft...

Previous studies have demonstrated the utility of fluorescence in situ hybridization (FISH) as an ancillary method in the diagnostic workup of histopathologically ambiguous melanocytic neoplasms. A combination of probes targeting 3 loci on chromosome 6 and 1 on 11q has been reported to distinguish unequivocal melanomas and nevi with a sensitivity and specificity of 87% and 96%, respectively. Ho...

Individuals with multiple melanocytic nevi oftentimes have melanocytic nevi, usually two, with similar clinical and histopathologic patterns that may be typical or atypical. The melanocytic nevi are known in common parlance as signature nevi [1, 2]. In addition to being aware of these nevi, finding multiple unconventional melanocytic nevi with architectural pattern asymmetric and/or cellular pa...