OBJECTIVE Impaired glucose metabolism is common in acromegaly, but it is not clear how glucose metabolism is impaired or what predicts its restoration after cure of the disease. To identify factors involved in the impairment of glucose metabolism in acromegaly, we evaluated clinical parameters before and immediately after surgical cure of the disease. DESIGN AND METHODS We retrospectively ana...

Objective: Studies report an increased prevalence of thyroid tumors among patients with acromegaly. Acromegaly often has a subtle presentation and is likely underdiagnosed. This report highlights the development of recurrent thyroid neoplasia in a patient with undiagnosed acromegaly and raises awareness of thyroid malignancy in patients with acromegaly. Case report: Mrs. R is a 47-year-old woma...

[Purpose] This study compared patients having active acromegaly with those having controlled acromegaly in terms of peripheral muscle strength, body composition, and functional capacity. We also examined the associations between these measures. [Methods] A total of 14 patients with active acromegaly, 12 patients with controlled acromegaly, and 12 healthy controls were subjected to isometric dyn...

CONTEXT The delay between onset of first symptoms and diagnosis of the acromegaly is 6-10 yr. Acromegaly causes typical changes of the face that might be recognized by face classification software. OBJECTIVE The objective of the study was to assess classification accuracy of acromegaly by face-classification software. DESIGN This was a diagnostic study. SETTING The study was conducted in ...

Acromegaly is the result of oversecretion of growth hormone and IGF-1 and the disease can affect several organ systems. Sleep Disordered Breathing (SDB) is a frequent disease in acromegaly patients. The mechanism of SDB is somewhat different in acromegaly patients than SDB in normal population. Although central apneas can be seen, obstructive apneas according to structural changes complicate th...

Introduction: This study was designed to evaluate potential reversibility of left ventricular (LV) dysfunction in patients with acromegaly following long-term control of disease. It is unknown, whether the cardiac changes induced by acromegaly can be completely reversed by long-term strict control of growth hormone (GH) excess by octreotide. Patients and Methods: We compared LV systolic and dia...

A male patient presented at the age of 30 with classic clinical features of acromegaly and was found to have elevated growth hormone levels, not suppressing during an oral glucose tolerance test. His acromegaly was originally considered to be of pituitary origin, based on a CT scan, which was interpreted as showing a pituitary macroadenoma. Despite two trans-sphenoidal surgeries, cranial radiot...

BACKGROUND Early diagnosis of a number of endocrine diseases is theoretically possible by the examination of facial photographs. One of these is acromegaly. If acromegaly were found, early in the course of the disease, morbidity would be lessened and cures more likely. OBJECTIVES, DESIGN, PATIENTS, MEASUREMENTS: Our objective was to develop a computer program which would separate 24 facial phot...

OBJECTIVE The aim of this study was to characterize the genetic variance of somatostatin receptor 5 (SSTR5) and investigate the possible correlation of such variants with acromegaly risk and different disease characteristics. DESIGN AND METHODS The SSTR5 gene coding region and 2000 bp upstream region was sequenced in 48 patients with acromegaly and 96 control subjects. Further, three single n...

Several studies have shown that patients with acromegaly are at increased risk of developing colorectal polyps and cancer. The prevalence of polyp in colon of patients with acromegaly was variously reported between 23% and 53%. This study was conducted to determine the prevalence of polyp and cancer of colon in patients with acromegaly. Twenty-three patients with acromegaly were evaluated with ...