Introduction: Obesity is a metabolic disease with an increase both in cell size (hypertrophy) and number (hyperplasia) following differentiation of new adipocytes. Adipogenesis well-orchestrated program which mitotic clonal expansion (MCE) occurs the early step followed by late terminal one. Methods: Aim study was to evaluate vitro effects cyanidin-3-O-glucoside (C3G), anthocyanin present many ...

The regulatory region of the neuronal nicotinic acetylcholine (nACh) receptor alpha 2 subunit gene is activated by the Brn-3b POU family transcription factor but not by the closely related factors Brn-3a and Brn-3c. This pattern of regulation has not previously been observed for other neuronally expressed genes, several of which, such as those encoding alpha-internexin or SNAP-25, are activated...

Objective(s): Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to the non-classical and classical oestrogen receptors, respectively, the present study was aimed to observe the osteoprotective effect of phytoestrogens on BPA-induced osteoblasts in hFOB 1.19 cells.Materials and Methods:...

Low birth weight (LBW) babies are associated with neonatal morbidity and mortality at increased risk for noncommunicable diseases (NCDs) in later life. However, the molecular determinants of LBW not well understood. Placental insufficiency/dysfunction is most frequent etiology fetal growth restriction resulting placental epigenetic processes suggested to be important regulators pregnancy outcom...

objective: estrogen receptor alpha protein status is determined by routine immunohistochemistry analysis in all malignant breast tumors. this assay has its limitations. rna based techniques are potential complements for immunohistochemistry but it must be noticed that gene silencing may occur at different levels from rna to protein. the aim of this study was the comparison of the results from t...

Syk (p72syk) is a 72-kDa, nonreceptor, protein-tyrosine kinase that becomes tyrosine-phosphorylated and activated in B lymphocytes following aggregation of the B-cell antigen receptor. To explore the subcellular location of activated Syk, anti-IgM-activated B-cells were fractionated into soluble and particulate fractions by ultracentrifugation. Activated and tyrosine-phosphorylated Syk was foun...

introduction: lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitiv...

Omega-3 fatty acids, which are abundant in fish oil, improve the prognosis of several chronic inflammatory diseases although the mechanism for such effects remains unclear. These fatty acids, such as eicosapentaenoic acid (EPA), are highly polyunsaturated and readily undergo oxidation. We show that oxidized, but not native unoxidized, EPA significantly inhibited human neutrophil and monocyte ad...