Premature chromosome condensation (PCC) has previously been observed in tissue culture and is believed to arise from asynchronous mitotic activity in multinucleated cells in which the affected nucleus is in interphase and at least one nucleus is in metaphase. Such cells have been noted following fusion induced by virus infection, spontaneously, and after treatment with cytochalasin B. The pheno...

Acute erythroleukemia is a rare form of acute myeloid leukemia recognized by its distinct phenotypic attribute erythroblasts proliferation. In this study, in vitro experiments showed that newly synthesized chalcone (ZH-254) inhibited cell proliferation, caused apoptosis, arrested the cycle G1 phase, and downregulated Fli-1 expression inhibiting promoter activity. vivo ZH-254 could effectively a...

Haematologica vol. 85(4):April 2000 2. Borgström GH, Vuopio P, De la Chapelle A. Polyploidy of the bone marrow. Scand J Haematol 1976; 17:12331. 3. Espinet B, Solè F, Woessner S, Florensa L, Besses C, Sans-Sabrafen J. Two new cases of near-tetraploidy in adult acute myeloid leukemia. Cancer Genet Cytogen 1998; 102:131-4. 4. Lemez P, Michalova K, Zemanova Z, et al. Three cases of near-tetraploid...

BACKGROUND Two electronic devices for self-measurement of blood pressure - a brachial monitor, the Omron M6, and a wrist monitor, the Omron R7 - were evaluated in two separate studies according to the International Protocol of the European Society of Hypertension. DESIGN The International Validation Protocol is divided into two phases: the first phase is performed on 15 selected participants ...

Background. The World Health Organization separates acute erythroid leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other entities with increased erythropoiesis–acute myeloid leukemia with myelodysplasia-related changes (≥20% myeloblasts of all nucleated cells) or myelodysplastic syndromes, and subdivides acute erythroid leukemia in...